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| Efficacy of Gegen Qinlian Decoction combined with liraglutide in the treatment of obese type 2 diabetes(T2DM) of dampness accumulation in spleen syndrome |
| Hits 1165 Download times 862 Received:June 10, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2020.12.09 |
| Key Words
liraglutide;Gegen Qinlian Decoction;obesity;type 2 diabetes;dampness accumulation in spleen syndrome |
| Author Name | Affiliation | | ZHOU Xiaoyi | Endocrine Department, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan 430061, China |
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| Abstract
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| [Objective] To investigate the efficacy of Gegen Qinlian Decoction combined with liraglutide in the treatment of obese type 2 diabetes(T2DM) of dampness accumulation in spleen syndrome.[Methods] A total of 90 obese T2DM patients of damp accumulation in spleen syndrome were selected and divided into 2 groups and each group has 45 patients randomly. Then control group received liraglutide,while the combination group received Gegen Qinlian Decoction combined with liraglutide.Both groups were treated for 12 weeks. Before and after the treatment,the body weight(W),body mass index(BMI),blood glucose(FPG,2 h PG),glycosylated hemoglobin(HbA1c),blood lipid(TC,TG,LDL-c),liver function(ALT,AST,GGT),homeostasis model assessment of insulin resistance(HOMA-IR) and the traditional Chinese medicine (TCM) symptom scores were monitored and compared.[Results] Before the treatment,there were no significant differences between groups of the indexes above,after the treatment of 12 weeks,all the indexes were superior than before,while the blood glucose,HbA1c,blood lipid,HOMA-IR and TCM symptom scores of the combination group were better than those of the control group.Meanwhile the differences of the W,BMI,liver function between the groups were not significant (P>0.05). There were three patients suffered from nausea accompanied with diarrhea and five with anorexia in the control group,while only two patients with anorexia were discovered in the combination group,the difference was significant(P<0.05).[Conclusion] Gegen Qinlian Decoction combined with liraglutide has equivalent effect with liraglutide single use in the amelioration of the W,BMI,liver function in obese T2DM of dampness accumulation in spleen syndrome,while the blood glucose,HbA1c,blood lipid,insulin resistance and TCM symptom scores of the combination group were superior to the control group. Furthermore,the combination group had less side effects than the control group. therefore,it is worthy of clinical recommendation. |
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