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| Meta-analysis of the efficacy of traditional Chinese medicine by clysis in the treatment of ulcerative colitis |
| Hits 1101 Download times 757 Received:August 04, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2020.12.15 |
| Key Words
traditional Chinese medicine;amino salicylic acid;clysis;ulcerative colitis;Meta-analysis |
| Author Name | Affiliation | E-mail | | LI Pengfan | Department of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China | | | LUO Yue | Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China | | | ZHANG Yuli | Department of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China | | | GU Sizhen | Department of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China | | | XUE Yan | Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China | | | PAN Ji | Endoscopy Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China | | | TANG Yini | Endoscopy Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China | | | XUE Shigui | Endoscopy Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China | | | DOU Danbo | Department of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China | doudanbo@126.com |
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| Abstract
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| [Objective] To systematically evaluate the efficacy and safety of the randomized controlled trial of Chinese medicineby clysisfor the treatment of ulcerative colitis(UC).[Methods] The Chinese and English literatures of all clinical randomized controlled trials(RCT)on the treatment of UC by clysisusing traditional Chinese medicine compound prescription were searched independently and systematically by two individuals. The database includesChina biomedical literature database (CBM),China national knowledge infrastructure(CNKI),VIP Database for Chinese Technical Periodicals(VIP),Wan Fang Database,PubMed Database,Embase,Cochrane Library. The retrieval time is from the database construction to February 2019. The two researchers independently extracted the data. In case of disagreement,they asked the other one to help solve the problem. Meanwhile,Review Manager5.3 software and Stata15.0 software were used to process the data of this study.[Results] A total of 17 literatures were included,including 1 597 patients with UC. The curative effect of the experimental group was superior to the control group[I2=0%,RR=1.31,95% CI=(1.25,1.37),P<0.0000 1].Subgroup analysis showed that it had better efficacycompared with clysis by aminosalicylic acid solution[I2=0%,RR=1.31,95% CI=(1.24,1.38),P<0.000 01],aminosalicylic acid suppository[I2=16%,RR=1.32,95% CI=(1.16,1.51),P<0.000 1],SASP[I2=0%,RR=1.29,95% CI=(1.23,1.36),P<0.000 01],or mesalazine[I2=4%,RR=1.37,95% CI=(1.22,1.54),P<0.000 01]. The clinical symptom scoreof clysiswith traditional Chinese medicine was higher than that of the control group[I2=23%,MD=-1.42,95% CI=(-2.38,-0.46),P=0.004]. The intestinal mucosal score ofclysis with traditional Chinese medicine was higher than that of the control group[I2=0%,MD=-0.29, 95% CI=(-0.50,-0.07),P=0.01]. Themayo scoreofclysiswith traditional Chinese medicine was higher than control group[I2=89%,MD=-2.50,95% CI=(-4.25,-0.75),P=0.005]. There was no significant difference in the incidence of adverse reaction between the two groups[I2=59%,RR=0.41,95% CI=(0.05,3.29),P=0.40]. Subgroup analysis showedthat there was no significant difference in the incidence of adverse reaction between the traditional Chinese medicinegroup andmesalazine[I2=0%,RR=0.14,95% CI=(0.02,1.11),P=0.06] or SASP[I2=82%,RR=1.20,95% CI=(0.02,77.88),P=0.93] group. The recurrence rate of traditional Chinese medicine compound clysis was lower than that of the control group[I2=0%,RR=0.34,95% CI=[0.16,0.72],P=0.005).[Conclusion] Compared with aminosalicylic acid drugs,the clysis of traditional Chinese medicine compoundhas better clinical efficacy and higher safety in the treatment of UC. |
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