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| Study on cognitive function characteristics of patients with chronic fatigue syndrome of main traditional Chinese medicine syndrome |
| Hits 1745 Download times 955 Received:August 15, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2021.01.09 |
| Key Words
chronic fatigue syndrome;cognitive function;traditional Chinese medicine syndrome |
| Author Name | Affiliation | E-mail | | HUANG Yao | Department of General Practice, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | SHI Jianing | Department of General Practice, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | ZHANG Zhenxian | Department of General Practice, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | zhenxianzhang@hotmail.com | | CHEN Ruohong | Department of General Practice, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | WU Zijin | Department of General Practice, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | | | WANG Zheng | Department of General Practice, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China | |
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| Abstract
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| [Objective] To observe the cognitive function characteristics of chronic fatigue syndrome (CFS) patients in major traditional Chinese medicine (TCM) syndromes types.[Methods] A case-control study was conducted to evaluate the cognitive function of patients with CFS of liver depression and spleen deficiency,liver and kidney deficiency,qi stagnation and phlegm obstruction,heart and spleen deficiency and normal group through MoCA scale and E-prime cognitive psychology test respectively.[Results] The total scores and module scores of MoCA scale in CFS patients in all major TCM syndrome types groups were lower than those in normal group (P<0.05). The MoCA total score,visual space and executive function module score,attention module score in liver and kidney deficiency group were lower than those in liver depression and spleen deficiency group and qi stagnation and phlegm obstruction group,and the delayed recall module score was lower than that in qi stagnation and phlegm obstruction group (P<0.05). The number of cases with mild cognitive impairment in each group was 2 cases with liver depression and spleen deficiency,7 cases with liver and kidney deficiency,0 cases with qi stagnation and phlegm obstruction,4 cases with deficiency of both heart and spleen,and 0 case with normal group. Compared with the normal group,the cognitive function level of liver and kidney deficiency group decreased (P<0.05). The B reaction time of CFS patients in the main TCM syndrome groups was longer than that of the normal group (P<0.05),while the accuracy of T2|T1 and One-back was lower than that of the normal group (P<0.05). Compared with the qi stagnation and phlegm obstruction group,the B reaction time was prolonged and the accuracy of T2|T1 was decreased in liver and kidney deficiency group and heart and spleen deficiency group. The accuracy of T2|T1 in liver and kidney deficiency group was lower than that in liver depression and spleen deficiency group,and the accuracy of One-back was lower than that in qi stagnation and phlegm obstruction group and heart and spleen deficiency group (P<0.05).[Conclusion] The patients in the main TCM syndrome types with CFS have impaired cognitive function,while the cognitive impairment in each group is different. Cognitive function was impaired more seriously in deficiency of the liver and kidney group or deficiency of both heart and spleen group,than those in qi stagnation and phlegm obstruction group or liver depression and spleen deficiency group. There were more patients with MCI in deficiency of liver and kidney group,so early intervention with Chinese medicine can prevent and cure cognitive impairment and delay MCI process. |
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