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| Research progress of integrated traditional Chinese and Western medicine in type 2 diabetic mellitus with sarcopenia |
| Hits 1697 Download times 1115 Received:September 10, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2021.01.28 |
| Key Words
type 2 diabetes mellitus;sarcopenia;spleen dominating muscle;protein metabolism |
| Author Name | Affiliation | E-mail | | NIU Hongjuan | School of Pharmacy in Minzu University of China, Key Laboratory of Ethnic Medicine in Ministry of Education, Beijing 100081, China | | | ZUO Xiangyu | School of Pharmacy in Minzu University of China, Key Laboratory of Ethnic Medicine in Ministry of Education, Beijing 100081, China | | | PANG Zongran | School of Pharmacy in Minzu University of China, Key Laboratory of Ethnic Medicine in Ministry of Education, Beijing 100081, China | zrpang@163.com |
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| Abstract
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| As a chronic complication of type 2 diabetes mellitus (T2DM),sarcopenia seriously affects the quality of life of the elderly and increases the medical and social burden. At present,there is no unified understanding of the diagnostic criteria of sarcopenia in western medicine,and the specific etiology and pathogenesis are not clear. Meanwhile,there is no targeted treatment yet. Diabetes can stimulate the aging patients to lose more muscle and change the composition of muscle and fat. Blood glucose may cause more serious damage to skeletal muscle than age. As the largest target organ of insulin,skeletal muscle protein metabolism imbalance may be the key pathogenesis of diabetic sarcopenia. Traditional Chinese medicine believes that "spleen dominates muscle",and clinical observation is highly related to the possible mechanism of T2DM sarcopenia,which can be used as theoretical guidance for internal and external treatment of traditional Chinese medicine. By summarizing the research progress of traditional Chinese medicine and western medicine on diabetic sarcopenia,this paper aims to provide new ideas for the explanation of disease mechanism and prevention and control of traditional Chinese medicine. |
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