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| A systematic review of the synergism and attenuation effects of Tripterygium Glycosides Tablet on the nephrotic syndrome |
| Hits 945 Download times 709 Received:November 20, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2021.02.16 |
| Key Words
Tripterygium Glycosides;nephrotic syndrome;systematic review |
| Author Name | Affiliation | E-mail | | YUAN Xinhui | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Zhichao | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HUANG Yuhong | Department of Clinical Pharmacology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | | | WANG Baohe | Department of Clinical Pharmacology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | wbh3423@sina.com | | DU Xi | Department of Clinical Pharmacology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | duxijob@aliyun.com |
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| Abstract
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| [Objective] To evaluate the synergistic and attenuating effects of Tripterygium Glycosides (TG) based on a systematic review of the efficacy and safety of TG in the treatment of nephrotic syndrome. [Methods] The search strategy was developed,and the domestic and foreign databases were searched. After the multi-layer screening,the original research that met the exclusion criteria was retained,and Meta-analysis was performed using Revman software. [Results] The Meta-analysis showed the test group was superior to the control group. There was a significant difference in complete remission rates between the two groups[RR=1.51,95%CI (1.33,1.70),P<0.000 01],and the test group was superior to the control group. After the heterogeneous literature was removed,there was a significant difference in 24 h urine protein between the two groups[MD=-0.53,95%CI (-0.61,-0.44),P<0.000 01]. The test group was superior to the control group. Regardless of whether or not the heterogeneity literature was excluded,there was no significant difference in the incidence of adverse reactions between the two groups[RR=0.88,95%CI (0.65,1.19),P=0.41,P>0.05]. It cannot be stated that the test group is superior to the control group. [Conclusion] The addition of TG on the basis of basic or conventional treatment has a synergistic effect,but it has not been proven to reduce the toxicity. |
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