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| Analysis on the mechanisms of treating different diseases with same method of Ganshuang Granule in treating cirrhosis with depression based on network pharmacology |
| Hits 961 Download times 593 Received:November 15, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2021.02.21 |
| Key Words
cirrhosis;depression;Ganshuang Granule;network pharmacology;immunoregulation;glucose and lipid metabolism |
| Author Name | Affiliation | E-mail | | FAN Yadong | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YU Shuang | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Xiaoyu | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | WANG Li | Tianjin Second People's Hospital, Tianjin 300192, China | | | BAI Liding | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CHANG Jun | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | BIAN Yuhong | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | bianyuhong_2012@163.com |
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| Abstract
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| [Objective] The common pathogenesis of cirrhosis and depression were analyzed through the network pharmacology,and the interaction network of Ganshuang Granules' traditional Chinese medicine-component-target network was constructed,so as to preliminarily explore the common pathogenesis of cirrhosis and depression and explore the mechanism of Ganshuang Granules' effect of treating two different diseases. [Methods] OMIM and Drugbank database were the targets related to cirrhosis and depression,combined with TCMID,TCMSP and Batman-TCM database and literature mining to obtain the ingredients and targets of Ganshuang Granules in the treatment of cirrhosis and depression. The Ingenuity Pathway Analysis (IPA) software was conducted to find common pathways and functions of cirrhosis and depression. The relevant targets of Ganshuang Granules for the treatment of two diseases were imported into BioGPS and Genecards database to obtain the tissue distribution and subcellular distribution,and pathway and function annotation analysis were conducted to map the disease treatment network. [Results] The common underlying pathogenesis of cirrhosis and depression may be related to immune dysfunction (dendritic cell maturation,Th1 and Th2 activation pathway,leucocyte migration),inflammation (acute phase response signaling,glucocorticoid receptor signaling,HMGB1 signaling,organ inflammation) and abnormal glucose and lipid metabolism (hepatic cholestasis,glucose metabolic disorder,diabetes). Ganshuang Granules may treat two diseases through immune regulation,anti-inflammation and glucose and lipid metabolism regulation. [Conclusion] The common pathogenesis of cirrhosis and depression involves immune dysfunction,inflammatory response and abnormal glucose and lipid metabolism. Ganshuang Granules can be used to treat two diseases through immune function and glucose and lipid metabolism regulation,which can provide directions for further explanation of the therapeutic effect and pharmacological mechanism. |
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