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| Correlation between visceral fat index,lipid accumulation index and syndromes of traditional Chinese medicine in high risk of stroke population with carotid atherosclerosis |
| Hits 912 Download times 661 Received:December 25, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2021.05.10 |
| Key Words
VAI;LAP;high-risk stroke population;carotid atherosclerosis;TCM syndrome |
| Author Name | Affiliation | E-mail | | ZHANG Li | The Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing 100078, China | | | ZHAO Jiayi | Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China | | | JIN Xianglan | The Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing 100078, China | | | SHI Xin | Beijing University of Chinese Medicine, Beijing 100029, China | | | XIE Xinran | Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China | | | CHEN Baoxin | The Second Clinical Medical College of Beijing University of Chinese Medicine, Beijing 100078, China | | | ZHANG Yunling | Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China | yunlingzhang2004@126.com。 |
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| Abstract
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| [Objective] Visceral adipose index (VAI) and lipid accumulation index (LAP) are new indicators that reflect visceral obesity,and there is little evidence for its relationship with the risk of cerebrovascular events. This study aimed to investigate the relationship between visceral fat index and lipid accumulation index and carotid atherosclerosis (CAS) in high-risk stroke patients.[Methods] Across-sectional study was performed from eight communities in urban areas of Northern China. A total of 9 215 high-risk of stroke participants were screened and basic information and traditional Chinese medicine (TCM) syndrome scale were collected. Two indicators including VAI and LAP,were calculated by formulas. TCM syndromes in patients with high risk of stroke and carotid atherosclerosis were analyzed by factor analysis.[Results] The 9 215 subjects[mean age (60±9) years,61.5% of women] were analyzed. The prevalence of CAS was 74.8%. Compared with the non-carotid arteriosclerosis group,the levels of waist circumference,WHtR,and LAP in the carotid arteriosclerosis group were significantly higher (P<0.001). A total of 5 syndrome elements were extracted from arteriosclerosis group including qi deficiency,yin deficiency,phlegm-dampness,fire heat,and blood stasis. Incidence of carotid atherosclerosis in fire heat syndrome,blood stasis syndrome and phlegm-dampness syndrome in the carotid arteriosclerosis group were higher than that in the non-carotid arteriosclerosis group (P<0.001). There was obvious difference in VAI incidence of carotid arteriosclerosis between yin deficiency syndrome and qi deficiency syndrome (P<0.001). There was obvious difference in LAP incidence of carotid arteriosclerosis between fire heat syndrome,yin deficiency,qi deficiency,and phlegm-dampness (P<0.001 or P<0.05).[Conclusion] In the high-risk stroke population with carotid arteriosclerosis,syndrome elements such as phlegm-dampness,fire heat,and blood stasis are more prominent. The internal organs are located in the liver,spleen,and kidney. The distribution of syndromes is characterized by deficiency syndromes such as qi deficiency and yin deficiency,and excess syndromes such as fire heat,phlegm-dampness,and blood stasis. The disease mechanism mainly belongs to mixture of deficiency and excess,mostly attributes to excess syndromes. |
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