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| Study on the regulation effect of magnesium salvianolic acetate on inflammatory factors and mRNA limbs ischemia-reperfusion injury in rats |
| Hits 1399 Download times 690 Received:January 02, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.05.25 |
| Key Words
ischemia-reperfusion;inflammatory factor;magnesium salvianolic acetate;limb |
| Author Name | Affiliation | | GU Yan | Tianjin First Central Hospital, Tianjin 300192, China | | HOU Likun | Tianjin First Central Hospital, Tianjin 300192, China | | LIU Hui | Tianjin First Central Hospital, Tianjin 300192, China | | HE Ju | Tianjin First Central Hospital, Tianjin 300192, China |
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| Abstract
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| [Objective] To investigate the protective effect of magnesium salvianolate acetate on limb ischemia-reperfusion injury,though investigating the changes of serum proinflammatory cytokines interleukin-6 (IL-6),tumor necrosis factor-α (TNF-α),interleukin-1β (IL-1β),interleukin-10 (IL-10) and their mRNA expression during limb ischemia-reperfusion injury.[Methods] A rat model of limb ischemia-reperfusion injury was established. The rats were divided into four groups,and the levels of inflammatory cytokines IL-6,TNF-α,IL-1β and IL-10 and the changes of mRNA in different groups during limb ischemia-reperfusion injury were compared. Then determined the effect of magnesium salvianolic acetate on inflammatory cytokines and their mRNA.[Results] The levels of TNF-α,IL-6 and IL-1β and their mRNA expression in the magnesium salvianolic acetate treatment group were significantly lower than those in the control group,and the IL-10 level and mRNA expression were significantly increased.[Conclusion] Magnesium salvianolate acetate can decrease the concentration of inflammatory cytokines in plasma by up regulating the level and mRNA expression of anti-inflammatory cytokines,which can reduce the degree of tissue injury during ischemia-reperfusion,thus playing a protective role. |
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