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| Research progress of 5-fluorouracil cardiotoxicity and prevention and treatment of traditional Chinese medicine |
| Hits 1566 Download times 1325 Received:January 20, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.05.26 |
| Key Words
5-fluorouracil;cardiotoxicity;research progress;prevention and treatment of traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | XU Yue | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Yuanyang | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | QI Xin | Department of Cardiology, Tianjin People's Hospital, Tianjin 300121, China | | | WEI Liping | Department of Cardiology, Tianjin People's Hospital, Tianjin 300121, China | weilipingme@163.com。 |
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| Abstract
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| 5-fluorouracil(5-FU) is a commonly used clinical anti-tumor drug. It has a good clinical effect on malignant tumors of epithelial origin,such as gastrointestinal tumors,head and neck tumors,breast cancer,etc.,but the cardiotoxicity of 5-FU during chemotherapy severely limits its clinical application. At present,the mechanism of cardiotoxicity induced by 5-FU mainly includes thrombosis after endothelial injury,increased metabolism leads to increased energy consumption,oxidative stress leads to cell damage,myocardial ischemia caused by coronary artery spasm,and myocardial ischemia caused by decreased red blood cell transfer oxygen capacity. Pay attention to the toxic side effects of 5-FU on the heart,strengthen the monitoring and management of the heart of chemotherapy patients,and actively develop special-effect cardioprotective agents,which can improve the quality of chemotherapy and improve the survival rate of patients. In order to better study the cardiotoxicity caused by 5-FU,this paper reviews the pathological features,potential mechanism of action,incidence,clinical manifestations,clinical prevention and treatment of traditional Chinese medicine caused by 5-FU. |
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