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| Analysis on the 2-year survival-on-drug of tripterygium glycoside and methotrexate in patients with rheumatoid arthritis |
| Hits 777 Download times 544 Received:March 15, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.07.09 |
| Key Words
rheumatoid arthritis;tripterygium glycoside;methotrexate;survival-on-drug;propensity score matching;adverse effects |
| Author Name | Affiliation | E-mail | | SHI Min | Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China | | | JI Wei | The Rheumatology Ward of Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China | weiweiji1103@163.com |
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| Abstract
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| [Objective] By analyzing the 2-year survival-on-drug (SOD) of tripterygium glycoside (TG) and methotrexate (MTX) in rheumatoid arthritis (RA) patients,to compare the difference of SOD and influencing factors.[Methods] Patients with RA who were admitted to the rheumatology ward of Jiangsu Provincial Hospital of Chinese Medicine from May 2016 to August 2019 and met the requirements were selected. Observation time was 2 years. After propensity score matching (PSM) with SPSS 25.0,143 patients in the observation group (TG group) and 143 patients in the control group (MTX group) were respectively applied and 2-year SOD and reasons for discontinuation were compared.[Results] 1) In terms of 2-year SOD:there's no significant differences between the 2-year SOD of two groups (P>0.05). In the TG group,the patients of low clinical disease activity index (CDAI) whose 2-year SOD was higher than the high CDAI (P<0.01). In the MTX group,the patients of low,moderate CDAI whose 2-year SOD were higher than high CDAI (P<0.05),the patients haven't hospitalized whose 2-year SOD were higher than patients were hospitalized (P<0.001). 2) In terms of the reasons for drug withdrawal:① The number of patients in the TG group who voluntarily stopped drugs due to improvement was higher than that in the MTX group (P<0.01),and the number of patients who stopped drugs due to damage to the blood system was lower than that in the MTX group (P<0.05). ② In terms of drug survival time:the self-stopping time of the TG group due to improvement was shorter than that of the MTX group,and the stopping time of the observation group due to poor control,liver function damage and gastrointestinal discomfort was longer than that of the MTX group,with statistically significant differences (P<0.05).[Conclusion] There was no significant difference in 2-year SOD between TG and MTX. The 2-year SOD of TG and MTX were both affected by the CDAI,and the MTX group was also affected by hospitalization. In terms of the reasons for drug withdrawal:In terms of the drug withdrawal,the number of patients in TG group was more than that in the MTX group because of heath improvement. The number of patients of the MTX group was more than that in the TG group because of the blood system damage. By analysis of drug survival time,compared with the MTX group,the TG group showed faster onset,better efficacy,and better tolerance to liver function involvement,gastrointestinal discomfort. |
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