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| Effects of Yiqi Huoxue Jiedu Prescription combined with chemotherapy on advanced pancreatic cancer patients |
| Hits 814 Download times 618 Received:April 10, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.07.10 |
| Key Words
Yiqi Huoxue Jiedu Prescription;advanced pancreatic cancer;tumor marker;immunoglobulin;galactose lectin-9 |
| Author Name | Affiliation | | QIAO Weichao | Oncology Department, The Third Hospital of Chengde, Chengde 067000, China | | TIAN Tian | Nursing Department, The Third Hospital of Chengde, Chengde 067000, China | | XIA Qing | Oncology Department, The Third Hospital of Chengde, Chengde 067000, China | | ZHANG Niu | Pharmacy Department, The Third Hospital of Chengde, Chengde 067000, China |
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| Abstract
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| [Objective] To explore the clinical effect of Yiqi Huoxue Jiedu Prescription combined with chemotherapy in the treatment of advanced pancreatic cancer,and analyze its effects on the serum CEA,POA,PCAA,immunoglobulin and galactose lectin-9 levels.[Methods] The 94 patients with advanced pancreatic cancer who were treated in our hospital from February 2015 to May 2017 were selected and randomly divided into observation group and control group,with 47 cases each. The control group received chemotherapy,and the observation group was treated with Yiqi Huoxue Jiedu Prescription on the basis,and the therapeutic effects of the two groups were analyzed and compared.[Results] The remission rates of objective disease in the observation group and,and the therapeutic effect in observation group was significantly better than that in control group (P<0.05). After treatment,the serum CEA,POA and PCAA levels in the observation group were significantly lower than those in control group(P<0.05). After treatment,the levels of p75,TrkA,TrkB,NGF and BDNF in the observation group were significantly lower than those in the control group(P<0.01). The levels of cytokines TNF-α,IFN-γ, IL-2 and IL-12 in the observation group were significantly higher than those in the control group (P<0.01). The level of immunoglobulin in observation group was significantly higher than that in control group,and the level of Gal-9 was significantly lower than that in the control group(P<0.01). The adverse reactions in two groups included thrombocytopenia,leukopenia,upper gastrointestinal reaction,diarrhea,etc. The incidence of upper gastrointestinal reaction and diarrhea in observation group was significantly lower than that in control group(P<0.05),and there was no significant difference in the incidence of thrombocytopenia and leukopenia between two groups (P>0.05).[Conclusion] The combination of Yiqi Huoxue Jiedu Prescription and chemotherapy can significantly improve the therapeutic effect of advanced pancreatic cancer patients,reduce the level of relevant molecules in nerve infiltration,reduce toxic and side effects,and enhance the immune response of the body. |
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