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| Data mining and biological mechanism exploration of Professor ZHAO Jinxi's core prescription in the treatment of type 2 diabetes mellitus |
| Hits 753 Download times 499 Received:February 16, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.07.18 |
| Key Words
network pharmacology;ZHAO Jinxi;data mining;type 2 diabetes mellitus;target |
| Author Name | Affiliation | E-mail | | SUN Ruixi | Department of Nephropathy and Endocrinology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China | | | FU Qiang | Department of Nephropathy and Endocrinology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China | | | WANG Doudou | Department of Nephropathy and Endocrinology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China | | | NAN He | Department of Nephropathy and Endocrinology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China | | | WU Shuang | The Second Affiliated Hospital Of Zhejiang Chinese Medical University, Hangzhou 310005, China | | | ZHAO Jinxi | Department of Nephropathy and Endocrinology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China | zhaojinximd@126.com |
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| Abstract
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| [Objective] Based on the data mining and network pharmacology technology,the core compatibility,potential targets and action mechanism of Professor ZHAO Jinxi's drugs for treating type 2 diabetes mellitus (T2DM) were discussed and studied.[Methods] The medical records of 325 cases of T2DM treated by Professor ZHAO Jinxi were collected,and the compatibility of core drugs was screened by association rules algorithm. TCMSP platform was used to screen the active ingredients of core prescriptions,and STITCH,TTD,DrugBank,GAD and DisGeNET databases were used to screen drugs and T2DM-related targets. MCODE algorithm in Cytoscape is used to identify the functional modules,and ClueGO plug-in is used to analyze the functions.[Results] The core combination of 6 drugs including Scutellaria baicalensis Georgi,Radix Puerariae,Salvia miltiorrhiza Bunge,Agrimonia pilosa,Lychee Seed and Cortex Lycii was screened out by correlation analysis. Through network pharmacological analysis,58 drug-disease related targets were obtained and 5 functional modules were identified. The 18 related pathways were obtained by KEGG pathway analysis of important targets.[Conclusion] The treatment of T2DM with core prescription is a multi-component,multi-target,multi-link and synergistic process. Its target may be SLC2A2,SLC2A4,TNF,PPARA and PPARG,and it can play a role by regulating fat factor signal pathway and PPAR signal pathway. |
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