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Based on network pharmacology and molecular docking analysis of the mechanism of Qishen Yiqi dripping pill in the treatment of acute coronary syndrome
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DOI   10.11656/j.issn.1672-1519.2021.07.23
Key Words   Qishen Yiqi dripping pills;acute coronary syndrome;acute myocardial infarction;unstable angina pectoris;network pharmacology;molecular docking
Author NameAffiliationE-mail
WANG Shuo Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China  
DU Xuechen Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China  
ZHAO Jia Tianjin Chest Hospital, Tianjin 300222, China  
ZHOU Jia Tianjin Chest Hospital, Tianjin 300222, China  
LI Chunjie Tianjin Chest Hospital, Tianjin 300222, China ykwn@sina.com 
Abstract
    [Objective] To analyze the effective components,targets and pathways of Qishen Yiqi dripping pills (QSYQ) in the treatment of acute coronary syndromethrough network pharmacology and molecular docking methods,and to explore its mechanism.[Methods] To search for the active ingredients and corresponding targets of QSYQ throughTCMSP,Batman platform. To obtain common targets for QSYQ,acute myocardial infarctionand unstable angina pectoris,through GeneCards,OMIM,TTD platform screens disease-related targets. To construct the target network diagram and PPI network diagram through STRING platform. Through DAVID platform to perform GO function and KEGG pathway enrichment analysis,and finally perform molecular docking according to the Autodock Tools 1.5.6 software.[Results] A total of 130 active ingredients of QSYQ for the treatment of AMI and UA were screened,and 36 potential targets were selected. There were 7 key targets selected. It was found that was the positive regulationresponse to hypoxia of the nitric oxide biosynthesis,cell response to lipopolysaccharide,extracellular space and TNF signaling pathways,NF-kappa B signaling pathway,NOD-like receptor signaling pathway,HIF-1 signaling pathway played a key role in the treatment of ACS by QSYQ.[Conclusion] The main active ingredients of QSYQ were luteolin,quercetin,ginsenoside rh2 and Tanshinone Ⅱ A,which can treat ACS through multiple targets and multiple pathways.

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