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| Study on antioxidant activity and chemical components of excreta extracts from Periplaneta americana L. |
| Hits 841 Download times 622 Received:March 24, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.08.23 |
| Key Words
Periplaneta americana L.;gut flora;antioxidant activity;chemical constituent |
| Author Name | Affiliation | E-mail | | WANG Ziyan | Tianjin Key Laboratory of Traditional Chinese Medicine Chemistry and Analysis, Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WU Dan | Tianjin Key Laboratory of Traditional Chinese Medicine Chemistry and Analysis, Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | NIU Lu | Tianjin Key Laboratory of Traditional Chinese Medicine Chemistry and Analysis, Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Yuefei | Tianjin Key Laboratory of Traditional Chinese Medicine Chemistry and Analysis, Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CHAI Xin | Tianjin Key Laboratory of Traditional Chinese Medicine Chemistry and Analysis, Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | chaix0622@tjutcm.edu.cn |
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| Abstract
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| [Objective] To explore the antioxidant activity and chemical components of excreta extracts from Periplaneta americana L.[Methods] DPPH free radical scavenging method was used to investigate the antioxidant capacity of the excreta extracts from Periplaneta americana L. The chemical components were separated by using solvents extracting, macroporous resin and high performance liquid chromatography, and identified by mass and nuclear magnetic resonance spectrum.[Results] The half inhibitory concentration (IC50) of DPPH free radical scavenging assay was 44.53 μg/mL, which shows the obvious antioxidant activity of the excreta extracts from Periplaneta americana L. Twelve compounds isolated from the extracts were respectively identified as catechol(1), benzoic acid(2), oxindole (3), 5-hydroxyindolin-2-one (4), 8-hydroxy quinoline-2-carboxylic acid (5), 6-hydroxy-2(1H)-quinolinone, catechol (6), 8-hydroxy-2(1H)-quinolinone (7), quinolin-2(1H)-one (8), 6-hydroxy-3, 4-dihydro-1H-quinolin-2-one (9), 5-hydroxy-3, 4-dihydro-1H-quinolin-2-one (10), 8-hydroxy-3, 4-dihydro-1H-quinolin-2-one (11), and 3, 4-dihydro-1H-quinolin-2-one (12), based on the physical properties and spectral data.[Conclusion] The excreta extract of Periplaneta americana L. shows obvious antioxidant activity. The components isolated were mainly quinolones. |
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