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| Predictive analysis of quality marker in Xuebijing Injection based on “five principles” |
| Hits 807 Download times 687 Received:May 10, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.08.24 |
| Key Words
Xuebijing Injection;quality marker;five principles |
| Author Name | Affiliation | E-mail | | CAI Nan | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Traditional Chinese Medicine Research Center, Tasly Holding Group Co. Ltd., Tianjin 300410, China | | | CAO Ningning | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHAO Libin | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Zhendong Guangming Pharmaceutical Research Institute, Beijing 100085, China | | | PEI Shuai | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Xiaoxuan | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Wanjing | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XIAO Xuefeng | School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | kai1219@163.com | | LIU Changxiao | State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300301, China | liuchangxiao@163.com |
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| Abstract
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| [Objective] To explore the quality marker (Q-marker) of Xuebijing Injection based on the "five principles" of Q-marker of traditional Chinese medicine:transmission and traceability, specificity, effectiveness, measurability and compatibility environment of compound prescriptions.[Methods] The relevant literature on the chemical constituents, pharmacokinetics, pharmacological activities, clinical application and quality control of Xuebijing Injection were retrieved in the databases such as CNKI, Wanfang, Pumbed and Medline. On the basis of this, the Q-marker of Xuebijing Injection are predicted and analyzed based on the "five principles" of Q-marker of traditional Chinese medicine.[Results] The hydroxysafflor yellow A, salvianolic acid B, paeoniflorin, senkyunolide I and senkyunolide H could be used as Q-marker of Xuebijing Injection.[Conclution] This study predicted the Q-marker of Xuebijing Injection, which could provide reference for its follow-up clinical and quality control research. |
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