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| Master of traditional Chinese medicine Academician WANG Qi's prescription excavation for clinical treatment of prostatic hyperplasia and exploration of medicine ideas |
| Hits 1050 Download times 572 Received:March 16, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.09.05 |
| Key Words
benign prostatic hyperplasia;prescriptions mining;medication idea;WANG Qi |
| Author Name | Affiliation | E-mail | | LIU Dan | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China | | | TANG Yibo | School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China | | | BAI Xue | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China | | | CHEN Yafei | School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China | | | LIU Guimin | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China | | | FAN Xiaolei | School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China | | | MA Ru | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China | | | CHANG Zhenghui | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China | | | LI Boyi | School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China | | | LI Lingru | National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing 100029, China | | | ZHENG Yanfei | National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing 100029, China | yanfei_z@163.com | | LIU Zhenquan | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China
National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing 100029, China | lzqbzy@sina.com |
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| Abstract
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| [Objective] To explore and analyze the regularity and characteristics of the prescriptions of Academician WANG Qi's clinical treatment of benign prostatic hyperplasia(BPH),and provide ideas and reference for clinical treatment of traditional Chinese medicine(TCM).[Methods] The clinical cases of BPH from Academician WANG Qi's outpatient clinic from September 2016 to June 2019 were collected and collated. After screening for inclusion and exclusion criteria and standardization of data,the cases were checked by three persons and entered into the "TCM Inheritance Support System(V2.5)" software,and finally the platform big data algorithm was used for prescriptions mining and analysis.[Results] A total of 75 prescriptions were included,involving 154 herbs. According to the statistics,the herbs of using frequency for the treatment of BPH,nature and flavour,channel tropism,key herbs,association rules of herb combinations and combinations of new prescriptions were obtained. Top 8 herbs with using frequency were whitmania pigra whitman,semen vaccariae,linderae radix,semen persicae,radix paeoniae rubra,cinnamomum cassia presl,poria,moutan cortex radicis,which can be seen to add herbs to Guizhi Fuling Pill. The frequency of four nature from high to low was cold,calm,warm,cool and hot. The frequency of five flavours from high to low was bitter,sweet,pungent,salty,astringent and sour. Twelve core herb combinations were excavated,and six new prescriptions were obtained based on the evolution.[Conclusion] In the clinical treatment of BPH,Academician WANG Qi focused on the pathogenesis characteristics of deficient root and excessive superficial,and proposes the pathogenesis theory of "kidney qi deficiency and blood stasis block". In addition,he also flexibly applied the idea of "main prescription for primary disease" and the concept of discussion on staging treatment. Academician WANG Qi believed that the treatment of BPH should be based on the principle of "dredge",the three methods of dissipating blood stasis,eliminating accumulation and dredging water channels should be combined as the treatment method. Moreover,the medication was mainly based on replenishing qi,activating blood and resolving aggregation,resolving phlegm,softening hard mass and promoting urination. |
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