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| Meta analysis of Yiqi Huoxue method in treating acute exacerbation of chronic obstructive pulmonary disease |
| Hits 874 Download times 478 Received:May 06, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.09.15 |
| Key Words
acute exacerbation of chronic obstructive pulmonary disease;Yiqi Huoxue method;Meta analysis |
| Author Name | Affiliation | E-mail | | MA Yuanhong | Beijing University of Chinese Medicine, Beijing 100029, China
Department of Internal Medicine, Fangshan Hospital of Beijing University of Traditional Chinese Medicine, Beijing 102400, China | | | LI Yan | Department of Emergency, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100700, China | | | LI Airu | Department of Internal Medicine, Fangshan Hospital of Beijing University of Traditional Chinese Medicine, Beijing 102400, China | | | GAO Yan | Department of Internal Medicine, Fangshan Hospital of Beijing University of Traditional Chinese Medicine, Beijing 102400, China | | | LI Wei | Department of Internal Medicine, Fangshan Hospital of Beijing University of Traditional Chinese Medicine, Beijing 102400, China | | | PU Linqian | Department of Internal Medicine, Fangshan Hospital of Beijing University of Traditional Chinese Medicine, Beijing 102400, China | | | SU Lianhua | Department of Internal Medicine, Fangshan Hospital of Beijing University of Traditional Chinese Medicine, Beijing 102400, China | | | ZHANG Hong | Department of Internal Medicine, Fangshan Hospital of Beijing University of Traditional Chinese Medicine, Beijing 102400, China | hong_xueming@sina.com |
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| Abstract
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| [Objective] To systematically evaluate the effectiveness and safety of Yiqi Huoxue method in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).[Methods] Seven Chinese and English databases including CNKI and PubMed were searched by computer,and the search time limit was from the establishment of the database to July 2019 to collect clinical randomized controlled trials(RCT) related to the treatment of AECOPD by Yiqi Huoxue method. Two researchers were needed to independently screen the literature and extract the relevant data according to the standard,and then the quality of the randomized controlled trial literature was evaluated by the bias risk assessment tool Cochrane,and the Meta analysis was performed by RevMan 5.3 software. The clinical efficacy,pulmonary function and blood gas improvement of Yiqi Huoxue method in the treatment of AECOPD were systematically evaluated. A total of 11 RCT articles were included,including 818 patients.[Results] The clinical effective rate of Yiqi Huoxue group was higher than that of the control group[RR=1.20,95%CI(1.14,1.27),P<0.000 01]). Pulmonary function improved significantly,including the percentage of respiratory volume in first second to forced vital capacity (FEV1/FVC)[MD=6.65,95%CI(3.97,9.33),P<0.000 01],FEV1[MD=0.40,95%CI(0.16,0.64),P<0.000 01],percentage of inspiratory volume in the first second to the expected value (FEV1% pre)[MD=9.10,95%CI(3.70,14.49),P<0.000 01] and forced vital capacity (FVC)[MD=1.52,95%CI(-0.21,3.26),P<0.000 01];at the same time,it can improve the blood gas level,including reducing the partial pressure of carbon dioxide (PaCO2)[MD=-8.14,95%CI(-13.25,-3.04),P<0.000 01] and increasing the partial pressure of oxygen in arterial blood (PaO2)[MD=7.28,95%CI(3.38,11.18),P<0.000 01] and (pH)[MD=0.06,95%CI(-0.02,0.13),P=0.001];at the same time,the top 6 Chinese herbs were used in clinical data,followed by Salvia miltiorrhiza,Radix astragali,Platycodon grandiflorum,Codonopsis pilosula,Atractylodes macrocephala and Glycyrrhiza uralensis. At present,the evidence shows that in the clinical treatment of AECOPD,we should pay attention to the use of traditional Chinese medicine,such as Salvia miltiorrhiza,Radix astragali,Platycodon grandiflorum,Codonopsis pilosula and so on. In addition,the incidence of adverse reactions in Yiqi Huoxue group was low.[Conclusion] It is suggested that on the basis of routine basic treatment of western medicine,the treatment of AECOPD,with traditional Chinese medicine for Yiqi Huoxue can improve clinical curative effect,improve lung function and regulate blood gas index. However,due to the limitation of the number and quality of included studies,there is still a lack of high-quality evidence to confirm the clinical efficacy of Yiqi Huoxue method,so more well-designed,large sample multicenter RCT are needed to verify it. |
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