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| Network pharmacological analysis of Duhuo Jisheng Decoction for treating different diseases with same method on rheumatoid arthritis and osteoarthritis |
| Hits 819 Download times 596 Received:April 28, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.09.23 |
| Key Words
network pharmacology;Duhuo Jisheng Decoction;rheumatoid arthritis;osteoarthritis;treating different diseases with same method;mechanism |
| Author Name | Affiliation | E-mail | | JI Yang | Traditional Chinese Medicine Hall, Heping District of the 983 Hospital of the Chinese People's Liberation Army, Tianjin 300175, China | | | DING Qing | Department of Rheumatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China
Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, Tianjin 300193, China | | | WU Yuanhao | Department of Rheumatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China
Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, Tianjin 300193, China | doctor.wuyh@gmail.com |
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| Abstract
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| [Objective] To explore the mechanism of Duhuo Jisheng Decoction for "treating different diseases with same method" of rheumatoid arthritis (RA) and osteoarthritis (OA) from the perspective of target and biological pathway by means of network pharmacology.[Methods] TCMSP,BATMAN-TCM,UniProt and GeneCards databases were used to predict targets of Duhuo Jisheng Decoction in the treatment of RA and OA. The online tool Venny was used to obtain the common targets,and then the STRING database was used to construct the protein-protein interaction Network among the common targets. The Cytoscape software was used to draw the mechanism Network of the "treating different diseases with same method" by the Duhuo Jisheng Decoction for RA and OA,and the Network Analyzer plug-in and MCODE plug-in were used for topology analysis and cluster analysis respectively. The DAVID database was used for enrichment analysis of biological processes and pathways.[Results] There were 194 targets in total for the treatment of Duhuo Jisheng Decoction on RA and OA,with 80 and 28 specific targets respectively. The modular analysis of the common targets yielded 5 modules,the main modules participated in 10 main related signal pathways,which can be reflected in the proliferation and invasion of synovial cells,pathological mechanisms such as abnormal bone formation,apoptosis of articular cartilage cells,and imbalance of extracellular matrix metabolism. Duhuo Jisheng Decoction may also treat RA and OA by regulating metabolic pathways and cGMP-PKG signaling pathways,respectively.[Conclusion] Duhuo Jisheng Decoction can expel wind and dampness,tonic joints,nourish the liver and kidney,regulate qi and blood to "tongzhi" rheumatoid arthritis,osteoarthritis and other "different diseases". Its mechanism of action is related to the common signal pathway that regulates RA and OA. |
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