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| Research on clinical efficacy of Shufeng Yiqi Decoction combined with salmeterol fluticasone on lung function, airway inflammation and cough variant asthma and influence on recurrence rate |
| Hits 1160 Download times 684 Received:April 25, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.10.09 |
| Key Words
cough variant asthma;Chinese medicine;Shufeng Yiqi Decoction;salmeterol fluticasone |
| Author Name | Affiliation | | LYU Conggai | Department of General Intenal Medicine, The Second Hospital of Shijiazhuang, Shijiazhuang 050000, China | | ZHANG Jin | Department of Respiratory, The Second Hospital of Shijiazhuang, Shijiazhuang 050000, China | | SUN Mingyu | Department of Cardiology, The Second Hospital of Shijiazhuang, Shijiazhuang 050000, China |
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| Abstract
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| [Objective] To investigate the clinical efficacy of Shufeng Yiqi Decoction combined with salmeterol fluticasone in the treatment of cough variant asthma(CVA) and its influence on lung function, airway inflammation and recurrence rate. [Methods] The 120 patients with CVA in our hospital from March, 2018 to March, 2020 were selected and randomly divided into two groups, with 60 cases in each group. The control group were given salmeterol fluticasone powder inhalation, once press each time, twice a day. The observation group were given Shufeng Yiqi Decoction on the basis of the treatment of the control group, and the course of treatment of both groups was for 8 weeks. The cough score, traditional Chinese medicine(TCM) syndrome score, forced expiratory volume on first second(FEV1), Maximum expiratory flow(PEF), and percentage of forced vital capacity(FEV1/FVC) were compared betweentwo groups before and after treatment, and the airway inflammation indexes including peripheral blood eosinophil percentage(BER), serum interleukin-5(IL-5), eosinophil cationic protein were compared betweentwo groups. The ECP level and MUC5AC content in sputum were compared betweentwo groups. The clinical efficiency and recurrence rate were compared betweentwo groups. [Results] After treatment, the scores of cough frequency and cough degree of the observation group were lower than those of the control group(P<0.01). The scores of expectoration, fatigue, shortness of breath and spontaneous sweating of the observation group were lower than those of the control group(P<0.01). FEV1, PEF, FEV1/FVC of the observation group were higher than those of the control group(P<0.01). BER, IL-5, ECP, MUC5AC of the observation group were lower than those of the control group(P<0.05), and the recurrence rate in 6 months after treatment was lower than that of the control group(P<0.05). The difference was statistically significant. [Conclusion] Shufeng Yiqi Decoction combined with salmeterol fluticasone can effectively relieve symptoms, improve lung function, inhibit airway inflammation, reduce recurrence rate, and it has a significant effect in the treatment of CVA. |
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