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| Meta-analysisof addition and subtraction of Liujunzi Decoction in the treatment of stable lung and spleen deficiency syndrome of chronic obstructive pulmonary disease |
| Hits 1267 Download times 692 Received:June 20, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.10.17 |
| Key Words
Liujunzi Decoction;chronic obstructive pulmonary disease;stable period;lung and spleen deficiency syndrome;Meta-analysis |
| Author Name | Affiliation | | LI Guofeng | Department of Respiratory Medicine of Tianjin Beichen Hosptial, Tianjin 300400, China | | LI Yi | Department of Respiratory Medicine of Tianjin Beichen Hosptial, Tianjin 300400, China |
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| Abstract
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| [Objective] To evaluate the efficacy and safety of addition and subtraction of Liujunzi Decoction in the treatment of stable lung and spleen deficiency syndrome in patients with chronic obstructive pulmonary disease. [Methods] Searching with PubMed, EMBASE, Cochrane Library, China knowledge Network, Wanfang, Weipu, China Biomedical Database, to collect the randomized controlled trial of addition and subtraction of Liujunzi Decoction in the treatment of stable lung and spleen deficiency syndrome of chronic obstructive pulmonary disease(COPD). Time was limited to the establishment of the database until March 2019 by RevMan 5.3. [Results] The total of 10 articles were included, including 870 patients. The results of Meta-analysis showed that the addition and subtraction of Liujunzi Decoction can improve the total effective rate[OR=3.10, 95%CI(2.13, 4.51), P<0.000 01], improve some pulmonary function indicators like FEV1[SMD=0.73, 95%CI (0.29, 1.18), P=0.001], FEV1/FVC[SMD=0.75, 95%CI (0.41, 1.09), P<0.000 1], however, the difference was not statistically significant in FVC[SMD=0.28, 95%CI (-0.24, 0.81), P=0.27]. It can improve some arterial blood gas analysis indicators like SaO2[SMD=0.94, 95%CI(0.21, 1.67), P=0.01], PaCO2[SMD=-1.71, 95%CI(-2.02, -1.40), P<0.000 01]), but the difference of PaO2[SMD=2.71, 95%CI(-0.44, 5.86), P=0.09] had no statistical significance. It can improve TCM syndrome scores (Cough[SMD=-1.16, 95%CI(-1.76, -0.55), P=0.000 2], expectoration[SMD=-0.80, 95%CI(-1.48, -0.13), P=0.02], short breath[SMD=-0.43, 95%CI (-0.71, -0.14), P=0.003], eat less[SMD=-1.00, 95%CI (-1.30, -0.70), P<0.000 01], abdominal distension[SMD=-1.09, 95%CI(-1.39, -0.79), P<0.000 01]). It can improve exercise endurance[SMD=0.94, 95%CI (0.10, 1.77), P=0.03], improve MMRC[SMD=-0.58, 95%CI(-0.82, -0.34), P<0.000 01]. There was no significant statistical difference in BMI between the two groups[SMD=-0.41, 95%CI(-1.37, 0.55), P=0.41]. [Conclusion] Addition and subtraction of Liujunzi Decoction has curative and effective advantages in the treatment of stable lung and spleen deficiency syndrome of chronic obstructive pulmonary disease. |
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