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| Research progress on the role of cholecystokinin in digestive system and central nervous system based on brain-gut axis theory |
| Hits 5486 Download times 1232 Received:July 20, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.10.25 |
| Key Words
cholecystokinin;brain-gut axis;digestive system;central nervous system |
| Author Name | Affiliation | E-mail | | ZHANG Xinning | Beijing University of Chinese Medicine, Beijing 100029, China | | | LI Xuejun | First Department of Brain Diseases, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China | | | MENG Fanxing | First Department of Brain Diseases, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China | | | CHEN Lu | First Department of Brain Diseases, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China | | | WU Yang | First Department of Brain Diseases, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China | | | GAO Yanjie | First Department of Brain Diseases, Dongfang Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100078, China | jane-852@163.com |
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| Abstract
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| The brain-gut axis is the bridge that communicates the human digestive system and the nervous system. Brain-gut peptide is an important factor in the construction of this bridge. As a typical brain-gut peptide, cholecystokinin is widely distributed in human digestive system, central nervous system, peripheral blood and other tissues and organs, and participates in many processes such as gastrointestinal exercise, appetite regulation, hormone secretion, and neuroprotection. It is closely related to advanced behaviors such as learning, memory, and emotion. It forms a two-way circular regulation loop through the brain-intestinal axis, which closely links the human central and gastrointestinal systems, and thus plays a role in various physiological and pathological processes. Based on the theory of brain-gut axis, the research progress in the digestive system and central nervous system is summarized. |
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