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| Study on stroke types and inflammatory factors levels of different syndromes in patients with ischemic stroke and dyslipidemia |
| Hits 769 Download times 506 Received:May 24, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.11.05 |
| Key Words
dyslipidemia;ischemic stroke;TCM syndrome;inflammatory factor;TOAST type |
| Author Name | Affiliation | E-mail | | LI Zhongkang | Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100700, China | | | YANG Huimin | Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100700, China | yanghuimin012005@163.com | | LIU Zhongqi | Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing 100700, China | | | SUN Chenchen | Dongfang Hospital Beijing University of Chinese Medicine, Beijing 100078, China | |
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| Abstract
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| [Objective] To investigate the differences of stroke types (TOAST type),Toll-like receptor 4 (TLR4),transforming growth factor-β-activated kinase 1 (TAK1),nuclear factor-κB p65 (NF-κB p65),interleukin 6 (IL-6) levels of different traditional Chinese medicine (TCM) syndromes in patients with dyslipidemia complicated with ischemic stroke. [Methods] 170 patients with ischemic stroke complicated with dyslipidemia and 10 healthy physical examinees were selected for analysis,and the general data (including age and gender),TOAST subtypes and levels of inflammatory factors including TLR4,TAK1,NF-κB p65,IL-6 were compared and the correlation were analized among different TCM syndromes. [Results] The TCM syndromes were mostly phlegm-stasis syndrome,followed by qi deficiency and blood stasis syndrome,and the other syndromes were less distributed. In terms of TOAST types,there were differences among various TCM syndromes (P<0.05),among which the syndromes of phlegm-stasis syndrome was mostly small artery occlusion stroke,while the syndromes of qi deficiency and blood stasis syndrome was mostly large artery atherosclerotic stroke,and the other syndromes showed little difference. The expressions of TLR4,TAK1 and NF-κB p65 were the highest in the phlegm-stasis syndrome (P<0.05),followed by qi deficiency and blood stasis syndrome (P<0.05). There was no significant difference between hyperactivity of liver yang syndrome and heat-phlegm and sthenic-fu syndrome (P>0.05). IL-6 expression level was the highest in qi deficiency and blood stasis syndrome (P<0.05). [Conclusion] Ischemic cerebral stroke complicated with dyslipidemia in patients with TCM syndrome distribution is given priority to phlegm-stasis syndrome. In the etiological classification of stroke,the phlegm-stasis syndrome is mainly manifested as small artery occlusion stroke,while the qi deficiency and blood stasis syndrome is mainly manifested as large artery atherosclerotic stroke. TLR4,TAK1,NF-κB p65,IL-6 and distribution in the different TCM syndrome types have certain regularity,which can be used as objective basis of classification in patients of ischemic stroke and dyslipidemia complicated. |
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