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| Effect of Lianhua Qingwen preparation on COVID-19: a Meta-analysis |
| Hits 1649 Download times 722 Received:December 10, 2020 |
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| DOI
10.11656/j.issn.1672-1519.2021.11.12 |
| Key Words
Lianhua Qingwen preparation;traditional Chinese medicine;COVID-19;Meta-analysis |
| Author Name | Affiliation | | TANG Yanli | Tianjin TEDA Hospital, Tianjin 300457, China | | WANG Jiming | Tianjin TEDA Hospital, Tianjin 300457, China | | YANG Cui | Tianjin TEDA Hospital, Tianjin 300457, China | | ZHUANG Tingyi | Tianjin TEDA Hospital, Tianjin 300457, China | | FU Jinping | Tianjin TEDA Hospital, Tianjin 300457, China |
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| Abstract
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| [Objective] To systematically review the efficacy and safety of Lianhua Qingwen preparation in the treatment of COVID-19. [Methods] We searched all randomized controlled trials (RCTs) of Lianhua Qingwen preparation intervening COVID-19 in PubMed,MEDLINE,Embase,Cochrane Collaboration,CNKI,VIP,Wanfang data,China Biology Medicine (CBM) from the establishment of the database to May 2020. The RevMan 5.3 software was applied for data analysis. [Results] A total of 5 RCTs with 824 cases of patients were enrolled in the study. Meta-analysis showed that compared with standard treatment of Western medicine,treatment combined with Lianhua Qingwen preparation could shorten the time of fever (MD=-1.04,95%CI=-1.60~-0.48,P=0.000 3),indicating that the combination of Lianhua Qingwen preparation can improve fever symptoms to some extent. It can improve cough symptoms (MD=-1.30,95%CI=-2.55~-0.05,P=0.04),reduce the number of cough (RR=1.72,95%CI=1.22~2.43,P=0.002),indicating that the combination of Lianhua Qingwen preparation can alleviate cough. It can improve fatigue symptoms (MD=-1.30,95%CI=-2.38~-0.22,P=0.02),reduce the number of fatigue (RR=1.72,95%CI=1.28~2.32,P=0.000 3),indicating that the combination of Lianhua Qingwen preparation can alleviate fatigue. It can improve the clinical total effective rate (RR=1.23,95%CI=1.12~1.34,P<0.000 1),improve lung CT (RR=1.21,95%CI=1.09~1.34,P=0.000 5),reduce number of patients with mild to severe disease (RR=0.45,95%CI=0.30~0.68,P=0.000 1),and improve inflammation index. Two of the six studies reported the occurrence of adverse events. [Conclusion] Compared with the conventional western medicine standard treatment,the combined use of Lianhua Qingwen preparation has a certain intervention effect on COVID-19 patients' fever,cough,fatigue and other clinical symptoms,total effective rate,lung CT,the number of patients with mild to severe diseases,inflammatory indicators,etc.,and has the effects of improving and shortening fever time,improving clinical symptoms and improving clinical efficacy,and its safety needs further study and confirmation. |
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