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| Diseased collateral mechanism of neovascularization in tumor micro-environment |
| Hits 659 Download times 509 Received:August 28, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.12.13 |
| Key Words
traditional Chinese medicine;pathogenesis;diseased collateral;tumor micro-environment;neovascularization |
| Author Name | Affiliation | | HE Wei | School of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang 712046, China | | ZHANG Yami | The Second Department of Oncology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712021, China | | HU Yong | School of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang 712046, China | | TONG Yajing | School of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang 712046, China |
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| Abstract
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| Neoplasms are neovascularization dependent diseases. Incomplete neovascularization in tumor micro-environment has multiple damaging effects such as increasing tumor interstitial hydraulic pressure, accelerating tumor cell invasion and metastasis, aggravating tumor cell deterioration, and suppressing immune response of immune cells. The abnormal changes of neoangiogenesis and proliferation in tumor micro-environment, morphological structure and pathological changes, vascular endothelial cell function are very similar to the collateral disease process in the collateral disease theory, namely "collateral deficiency" causes "toxic harming collaterals", hypertrophic collaterals. The changes of "jie collaterals" "sheng collaterals" "horizontal collaterals" "relaxation collaterals" lead to abnormal morphology and structure of neovascularization. "Collateral rupture" causing dysfunction of new blood vessels lead to high vascular permeability and lymphatic fluid retention. It has important theoretical guidance value of clarifying the direction and mechanism of traditional Chinese medicine in the intervention of tumor angiogenesis, and improving the effects of activating blood circulation and removing blood stasis on inhibition of angiogenesis to explore the mechanism of traditional Chinese medicine diseases and collaterals of neoplastic micro-environment neovascularization. |
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