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| Study on the protective effect of Tongmai Yangxin Pill on doxorubicin rats with chronic cardiac toxicity |
| Hits 669 Download times 427 Received:August 10, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.12.23 |
| Key Words
doxorubicin;Tongmai Yangxin Pill;cardiotoxicity;protection |
| Author Name | Affiliation | E-mail | | LYU Qingbo | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | PAN Junhua | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Yujing | . Tianjin Zhongxin Pharmaceutical Group Co., Ltd. Le Ren Tang Pharmaceutical Factory, Tianjin 300112, China | | | XU Jinpeng | . Tianjin Zhongxin Pharmaceutical Group Co., Ltd. Le Ren Tang Pharmaceutical Factory, Tianjin 300112, China | | | WANG Yi | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SHU Lexin | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | shulexin@tjutcm.edu.cn |
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| Abstract
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| [Objective] To observe the protective effect of Tongmai Yangxin Pills on chronic cardiac toxicity induced by doxorubicin in rats.[Methods] The rats model of chronic cardiac toxicity induced by adriamycin was established. The rats were treated with Tongmai Yangxin Pills to observe the diet, daily status, death rate, electrocardiogram, heart function, heart index, serum myocardial enzyme detection and myocardial tissue morphology.[Results] Compared with the blank control group, the growth rate of body weight of rats in the model group and the administration group was lower, the growth rate was slower, and the mortality rate increased. The general condition of rats in the model group was poor, but the general condition of rats was improved after the administration of Tongmai Yangxin Pills. At the fourth week, compared with the blank control group, the RR interval was significantly prolonged and the heart rate was significantly decreased in the model group. Compared with the model group, the RR interval was shortened and the heart rate was increased in the administration group. At the fourth week, compared with the blank control group, EF and FS in the model group were significantly decreased, while LVIDs and LVIDd were significantly increased, and FS in the administration group was higher than that in the model group. Compared with the blank control group at the eight week, EF and FS in model group decreased. At the tenth week, compared with the blank control group, EF and FS of the model group were significantly decreased, while LVIDs were significantly increased. Compared with the blank control group, the heart weight in the model group was significantly decreased, and the difference was statistically significant. At fourth week, compared with the model group, CK level in the administration group decreased. At the tenth week of administration, compared with the blank control group, LDH in the model group was significantly increased, and compared with the model group, LDH in the administration group was decreased.[Conclusion] Tongmai Yangxin Pills has protective effects on chronic cardiac toxicity induced by doxorubicin in rats. |
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