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| Metabolomic study on regulation of uric acid by nuciferine based on 1H-NMR spectra |
| Hits 590 Download times 617 Received:August 21, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2021.12.25 |
| Key Words
nuciferine;1H-NMR;hyperuricemia;metabolomics |
| Author Name | Affiliation | E-mail | | GAO Lixing | Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | WANG Liming | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 3001617, China | | | SUI Hongfei | Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | HAN Lifeng | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 3001617, China | hanlifeng@tjutcm.edu.cn |
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| Abstract
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| [Objective] To study the effect of nuciferine on hyperuricemia mice, and to screen for biomarkers related to hyperuricemia metabolism.[Methods] A long-term administration model for mice was used. After continuous administration for 14 days, proton nuclear magnetic resonance(1H-NMR) was used to detect plasma and urine samples from hyperuricemia mice.[Results] A total of 9 potential biomarkers were screened from plasma and urine samples by 1H-NMR analysis.[Conclusion] The metabolomics study of nuciferine in hyperuricemia mice further illustrates that the pathological process of hyperuricemia mainly involves tyrosine metabolism, citric acid metabolism, arginine and proline metabolism, and glycolysis and the gluconeogenesis pathway, which indicates that these potential biomarkers not only play an important role in early disease diagnosis, but also have great significance in the prevention of hyperuricemia. |
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