|
| Comparison of anti-inflammatory and analgesic effects of water extract and alcohol extract of Uyghur Tuti Decoction and their therapeutic effects on acute pharyngitis |
| Hits 637 Download times 409 Received:October 13, 2021 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2022.01.26 |
| Key Words
Tuti Decoction;alcohol extract;water extract;acute pharyngitis;analgesic and anti-inflammatory effect |
| Author Name | Affiliation | E-mail | | CUI Baining | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ABUDOUKADIER·Abulimiti | Hetian Uygur Medical Hospital, Hetian 848000, China | | | REHANGULI·Maimaitijiang | Hetian Uygur Medical Hospital, Hetian 848000, China | | | ADILI·Aisituola | Hetian Uygur Medical Hospital, Hetian 848000, China | | | HU Peng | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Yan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wangyan@tjutcm.edu.cn | | HE Xin | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Guangdong Pharmaceutical University, Guangzhou 510006, China | hexintn@163.com |
|
| Abstract
|
| [Objective] To study the anti-inflammatory and analgesic effects of Tuti decoction water extract and Tuti Decoction alcohol extract，and their therapeutic effects on acute pharyngitis were compared to lay experimental foundation for their medicinal development. [Methods] The anti-inflammatory animal models were used to figure out the effects of different extracts of Tuti Decoction on acute inflammation. Hot-plate procedure and writhing test in mice were adopted in experimental analgesic models，anti-inflammatory model of mouse ear edema induced by xylene，rat paw edema induced by complete Freund’s adjuvant and exudation of abdominal blood capillaries of mice were applied. Acute pharyngitis model in rats were adopted to investigate the treatment effect of Tuti Decoction water extract and Tuti Decoction alcohol extract. [Results] Compared with the model group，the positive group，the Tuti Decoction water extract group and Tuti Decoction alcohol extract group could significantly improve the pain threshold，reduce the abdominal vascular permeability of mice，reduce the ear swelling，and reduce the foot swelling（P<0.05）.The anti-inflammatory and analgesic effect of alcohol extract is better than that of water extract. Tuti Decoction can obviously reduce the keratinization of pharyngeal mucosa epithelium，reduce the infiltration of inflammatory cells，reduce the alveolar space of lung tissue，and reduce the infiltration of inflammatory cells in alveolar cavity. Compared with the model group，the content of TNF-α in the high and low dose group was significantly decreased （P<0.01）. [Conclusion] Tuti Decoction extract has a good therapeutic effect on acute pharyngitis in rats，and the therapeutic action on acute pharyngitis is achieved by reducing swelling，reducing exudation and relieving pain. The analgesic and anti-inflammatory effect of alcohol extract of Tuti Decoction is stronger than water extract，which lays experimental foundation for the subsequent formulation improvement. |
|
|
|
|
|
|
|
