|
| Therapeutic effect and mechanism of Xifeng Tongyu Kaiqiao Recipe combined with electroacupuncture on acute cerebral infarction |
| Hits 1266 Download times 563 Received:November 15, 2021 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2022.02.14 |
| Key Words
Xifeng Tongyu Kaiqiao Recipe;electro-acupuncture;acute cerebral infarction;inflammation;oxidative stress;nerve function |
| Author Name | Affiliation | | ZHAO Shaoning | Department of Encephalopathy Rehabilitation, Langfang Hospital of Traditional Chinese Medicine, Langfang 065000, China | | WANG Lianjun | Department of Encephalopathy Rehabilitation, Langfang Hospital of Traditional Chinese Medicine, Langfang 065000, China | | ZHANG Zhanpeng | Department of Encephalopathy Rehabilitation, Langfang Hospital of Traditional Chinese Medicine, Langfang 065000, China | | LIU Dequan | Department of Encephalopathy Rehabilitation, Langfang Hospital of Traditional Chinese Medicine, Langfang 065000, China | | CHANG Jingjing | Department of Encephalopathy Rehabilitation, Langfang Hospital of Traditional Chinese Medicine, Langfang 065000, China | | LU Yueying | Department of Encephalopathy Rehabilitation, Langfang Hospital of Traditional Chinese Medicine, Langfang 065000, China |
|
| Abstract
|
| [Objective] To explore the effect of Xifeng Tongyu Kaiqiao Recipe combined with electro-acupuncture on the patients with acute cerebral infarction.[Methods] The 164 patients with acute cerebral infarction were randomly divided into control group (41 cases, routine Western medicine treatment), electro-acupuncture group (41 cases, routine Western medicine+electroacupuncture treatment), decoction group (41 cases, routine Western medicine+Xifeng Tongyu Kaiqiao Recipe), combined group (41 cases, routine Western medicine+ Xifeng Tongyu Kaiqiao Recipe+electro-acupuncture). The changes of inflammation[tumor necrosis factor-α (TNF-α), high sensitivity C-reactive protein (hs-CRP), interleukin-1 β (IL-1β)], oxidative stress[malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO), glutathione peroxidase (GSH-Px)] and neurological function (NIHSS) before treatment, 1 week and 2 weeks after treatment, prognosis of the disease were compared among the 4 groups.[Results] There were statistically significant differences in the serum inflammatory factors, oxidative stress indexes and NIHSS scores by variance by repeated measurement analysis (P<0.05). After 1 week and 2 weeks, serum inflammatory factors, MDA levels and NIHSS scores of the four groups were lower than those before treatment (P<0.05), and those after 2 weeks were lower than those after 1 week (P<0.05), which in the combination group were lower than those in the other three groups after 1 week and 2 weeks (P<0.05), and those in the electro-acupuncture group and decoction group were lower than those in the control group (P<0.05). The serum SOD, NO and GSH PX in the four groups after 1 week and 2 weeks were higher than those before treatment (P<0.05), and those after 2 weeks were higher than those after 1 week (P<0.05), and those in the combination group after 1 week and 2 weeks were higher than those in the other three groups (P<0.05), and those in the electro-acupuncture group and decoction group were higher than those in the control group (P<0.05). The good prognosis rates of the combined group, electro-acupuncture group, which in the combination group was higher than those of the other three groups (P<0.05).[Conclusion] Xifeng Tongyu Kaiqiao Recipe and electro-acupuncture can reduce the inflammation, oxidative stress and neurological deficit in patients with acute cerebral infarction, and the combination of the two has better effect and can effectively promote the prognosis of the disease. |
|
|
|
|
|
|
|
