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| Mechanism of Shenshuning in preventing and treating renal interstitial fibrosis based on network pharmacology and molecular docking technique |
| Hits 544 Download times 399 Received:January 25, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.04.22 |
| Key Words
Shenshuning;renal interstitial fibrosis;network pharmacology;molecular docking;signaling pathway |
| Author Name | Affiliation | E-mail | | YU Wenwen | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibusion, Tianjin 300381, China | | | QIN Suyang | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibusion, Tianjin 300381, China | | | WANG Yaoguang | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibusion, Tianjin 300381, China | wangyaoguang1012@126.com |
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| Abstract
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| [Objective] To explore the potential mechanism of Shenshuning in preventing and treating renal interstitial fibrosis based on network pharmacology.[Methods] The chemical constituents of Shenshuning were obtained by searching TCMSP,Uniprot databases,and the corresponding target were found. Drug targets and disease targets were screened by Genecards,OMIM,TTD databases. The "component-target-pathway-disease" network was constructed by Cytoscape software. Then,KEGG signaling pathway enrichment and GO function enrichment were analyzed on the target. With the help of AutoDock software,the receptor and ligand were preprocessed and molecular docking.[Results] A total of 130 active components and 116 related targets of Shenshuning on renal interstitial fibrosis were screened out. KEGG analysis showed that these targets were mainly enriched in TNF,NF-κB,AGE-RAGE and other highly correlated signaling pathways. GO enrichment results showed that Shenshuning may play a role in the treatment of renal interstitial fibrosis through the regulation of inflammatory response,cell apoptosis,oxidative stress reaction and other processes. The molecular docking results showed that the active components of Shenshuning showed good binding activity among stigmasterol,tanshinone and isorhamnetin and the core targets. The binding activity of TNF and RELA with active components were better.[Conclusion] Shenshuning may prevent and treat renal interstitial fibrosis through various ways. |
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