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| Research progress of chemical constituents and pharmacological activities of Ligustri Lucidi Fructus in improving glucose and lipid metabolic disorders |
| Hits 529 Download times 424 Received:January 08, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.04.24 |
| Key Words
Ligustri Lucidi Fructus;glucose and lipid metabolism;bioactivity mechanism |
| Author Name | Affiliation | E-mail | | WANG Weiqiang | Chinese Medicine Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHU Tongtong | Chinese Medicine Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | DAI Yongna | Clinical Expertise Training Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | GAO Zhijie | Chinese Medicine Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | FU Zhifei | Chinese Medicine Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Erwei | Chinese Medicine Research Institute, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | liuwei628@tjutcm.edu.cn |
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| Abstract
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| Ligustri Lucidi Fructus is the dried and mature fruit of Ligustrum lucidum Ait,which belongs to the Oleaceae family. Polysaccharides,triterpenes,secoiridoids and flavonoids in Ligustri Lucidi Fructus can enhance insulin sensitivity,improve insulin resistance,and protect pancreatic β cells. They can regulate AMPK,AKT and PTP1B pathways. They can regulate immunomodulatory,inhibit the release of inflammatory factors and antioxidation which improves glucose and lipid metabolic disorders. In this study,based on systematic literature and books,we summarize the chemical constituents and pharmacological activities of Ligustri Lucidi Fructus in improving glucose and lipid metabolic disorders,and possible active mechanisms,which provides reference for further usage of Ligustri Lucidi Fructus in treating glycolipid metabolic diseases. |
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