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Factor analysis of nucleic acid turning negative time of novel coronavirus Omicron infection patients treated by integrated traditional Chinese and Western medicine in Tianjin area
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DOI   10.11656/j.issn.1672-1519.2022.05.02
Key Words   Tianjin area;novel coronavirus;Omicron variant;integrated traditional Chinese and Western medicine;nucleic acid turning negative time
Author NameAffiliationE-mail
SUN Hongyuan First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China  
ZHANG Yuan Tianjin Hospital of ITCWM Nankai Hospital, Tianjin 300100, China  
SHI Cunzhong First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China  
LIU Xiaoya First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China  
ZHAO Guifeng First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China  
ZHAO Qiang First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China  
CHEN Minghu First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China  
WU Zeng First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China  
LYU Shichao First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China  
ZHAO Xun Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China  
FENG Limin Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China  
LI Qiang Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China  
MA Yan Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China  
ZHANG Shaoqiang Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China  
CHEN Zhuoyang Tianjin Hospital of ITCWM Nankai Hospital, Tianjin 300100, China  
ZHANG Lei Tianjin Hospital, Tianjin 300211, China  
LI Guiwei First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China li-guiwei@163.com 
LIU Xinqiao First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China  
MAO Jingyuan First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China  
Abstract
    [Objective] To investigate the influencing factors of nucleic acid negative conversion time in patients infected with novel coronavirus Omicron variant treated with integrated Chinese and Western medicine in Tianjin area.[Methods] Screen electronic medical records of novel coronavirus Omicron variant infection patients,extract hospitalization number,gender,age,vaccination information,previous chronic diseases,clinical typing,combined early symptoms,onset date,admission date,date of first consultation of traditional Chinese medicine(TCM),dialectical drug use information of TCM at first diagnosis,nucleic acid negative conversion date,retrospective analysis method was adopted,the time of patients' nucleic acid test turning negative was used as the outcome observation index,and the patients were divided into groups with the mean value. The differences of clinical characteristic indexes between groups were compared. Multivariate linear regression analysis was used to evaluate the influencing factors of outcome.[Results] The 398 cases of medical records were screened,219 cases were excluded,and 179 cases were included in the study. After grouping,there were statistically significant differences between groups in the comparison of indicators such as complicated chronic diseases,complicated early symptoms,time difference between admission,intervention time of integrated traditional Chinese and Western medicine,and classification of TCM syndromes (P<0.05). Multiple linear regression analysis showed that there was a positive correlation between the time of nucleic acid conversion and chronic diseases,the intervention time of integrated traditional Chinese and Western medicine,and the classification of TCM syndromes (P<0.05).[Conclusion] Combined with chronic diseases,late intervention of integrated Chinese and Western medicine and dialectical classification of Chinese medicine as mixed syndromes can prolong the negative nucleic acid conversion time of patients infected with novel coronavirus Omicron variant.

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