|
| Improvement of Biling Weitong Granule on the ulcer healing quality and its effect on growth factors in Hp-positive peptic ulcer patients |
| Hits 584 Download times 407 Received:November 30, 2021 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2022.05.08 |
| Key Words
Biling Weitong Granule;Hp positive peptic ulcer;ulcer healing quality;growth factor;clinical research |
| Author Name | Affiliation | | YAO Peng | Department of Gastroenterology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | KANG Hongchang | Department of Gastroenterology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | WANG Jiang | Department of Gastroenterology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | LI Mingyue | Department of Gastroenterology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | FENG Lu | Department of Traditional Chinese Medicine, Tianjin Hongqiao District Xiyuzhuang Street Health Service Center, Tianjin 300130, China | | YIN Jie | Department ofTraditional Chinese Medicine, Tianjin Heping District Wudadao Street Community Health Service Center, Tianjin 300050, China |
|
| Abstract
|
| [Objective] To investigate the effect of Biling Weitong Granules on improving the quality of ulcer healing in patients with Hp positive peptic ulcer and its influence on growth factors.[Methods] A total of 86 Hp positive peptic ulcer patients who met the enrollment criteria in our hospital from January 2019 to June 2020 were divided into observation group (43 cases) and control group (43 cases) according to a random number table. Patients in the control group were treated with conventional triple therapy,and the observation group was treated with Biling Weitong Granules on the basis of the control group. Both groups were treated for 4 weeks.TCM syndrome scores were performed before and after the intervention. The C13-urea breath test (13C-UBT) was used to compare the conversion rate of helicobacter pylori between the two groups. Painless gastroscopy was performed to evaluate the maturity of the regenerative mucosa under the microscope,and pentagastrin was used for gastric acid. Secretory function assessment,serum vascular endothelial cell growth factor (VEGF) and basic fibroblast growth factor (bFGF) were measured by enzyme-linked immunosorbent technique,and the clinical efficacy was evaluated at the end of 8 weeks of treatment. All patients were followed up for 12 months. Comparison of follow-up recurrence rates between the two groups of patients.[Results] After treatment in the control group and the observation group,the scores of epigastric burning,soreness,heating,and abdominal distension were significantly lower than those before treatment (P<0.05). After treatment,the scores of epigastric burning pain,acid swallowing,heating and abdominal distension in the observation group were significantly lower than those in the control group (P<0.05). The negative conversion rate of Hp in the observation group was 90.70%,which was significantly higher than 67.44% in the control group,and the difference was statistically significant(P<0.05). The quality of ulcer healing in the observation group after 4 weeks of treatment was significantly better than that of the control group(P<0.01). The VEGF and bFGF of the control group and the observation group were significantly higher than those before the treatment after 4 weeks of treatment (P<0.05),and the VEGF and bFGF of the observation group were significantly higher than those of the control group after 4 weeks of treatment (P<0.05). The BAO,MAO,and PAO of the control group and the observation group were significantly lower than before treatment after 4 weeks of treatment (P<0.05),and the BAO,MAO,and PAO of the observation group were significantly lower than those of the control group after 4 weeks of treatment (P<0.05).The total effective rate of the observation group for 4 weeks was 95.35% which was significantly higher than that of the control group 79.07%(P<0.05). The observation group had a recurrence of 6.98% during a 12-month follow-up,which was significantly lower than 30.23% of the control group.[Conclusion] The treatment of Hp positive peptic ulcer with Biling Weitong Granules can effectively improve the quality of ulcer healing and the clinical efficacy,which is related to its anti-H. pylori,inhibition of gastric acid secretion,increase of growth factor expression,and can help reduce the recurrence of the disease. |
|
|
|
|
|
|
|
