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| Acupuncture for treatment of nocturnal enuresis in children：a systematic review and Meta-analysis |
| Hits 594 Download times 356 Received:December 10, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2022.05.16 |
| Key Words
acupuncture;nocturnal enuresis;Meta-analysis;randomized controlled trials |
| Author Name | Affiliation | E-mail | | ZHOU Bingying | Department of Urology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China | | | MA Diyuan | Department of Urology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China | | | TANG Junfeng | Department of Urology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China | | | CAO Fengqin | Department of Urology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China | | | ZHANG Lijuan | Department of Urology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China | | | QI Leilei | Department of Urology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China | miniaoqll@163.com |
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| Abstract
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| [Objective] This study aims to systematically review the efficacy and safety of acupuncture on nocturnal enuresis in children.[Methods] We performed a comprehensive search of medical literature,including Cochrane Central Register of Controlled Trials (CENTRAL),MEDLINE,EMBASE,CBM,and other databases. The date of the latest search of all databases was August 12th,2021. After two reviewers screened the studies,extracted data from including studies,and rated the quality of evidence independently,we performed meta-analysis using software of Revman version 5.3.[Results] A total of 11 studies with 1 013 randomized participants(521 in acupuncture group and 492 in control group) were included. The results of meta-analysis showed that,compared with the control group,the acupuncture group had statistically significant higher complete response rate[OR=2.43,95%CI(1.37,4.29),P=0.002,I2=69%],so did the statistical significance when compared with sham acupuncture group and herbal therapy group respectively. But there was no significant difference between acupuncture group and conventional drug group. Moreover,although acupuncture did not reduce the average number of nocturnal enuresis in comparison with control intervention,a significant decrease was found when compared to the placebo acupuncture[MD=-1.49,95%CI(-2.26,-0.72),P=0.000 2]. In terms of adverse events,there was no significant difference between acupuncture group and control group[OR=0.62,95%CI(0.04,8.72),P=0.72].[Conclusion] The existing evidence shows that acupuncture is more effective than traditional Chinese medicine and placebo acupuncture in the complete response rate of nocturnal enuresis in children,but it is similar when compared to conventional drug group. Acupuncture has a better effect than placebo acupuncture in improving the average number of enuresis per week. And acupuncture has similar safety compared to all these treatments. |
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