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| Prescription rules and mechanism of core drugs in the treatment of atrial fibrillation based on data mining and network pharmacology |
| Hits 541 Download times 359 Received:November 30, 2021 |
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| DOI
10.11656/j.issn.1672-1519.2022.05.23 |
| Key Words
atrial fibrillation;data mining;network pharmacology;medication rule |
| Author Name | Affiliation | | LIU Yu | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | MA Qian | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | WANG Zhe | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China |
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| Abstract
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| [Objective] Based on the modern literatures,to explore the prescription rules and core drugs of traditional Chinese medicine (TCM) in the treatment of atrial fibrillation (AF) and to explore the action mechanism of core drugs.[Methods] The literatures in CNKI,VIP,and Wanfang databases were searched,and the prescriptions for the treatment of atrial fibrillation were collected. The TCM transmission aid platform software (version 2.5) was used to classify and count the prescriptions that met the inclusion criteria in terms of frequency,nature and flavor,meridian tropism,four properties and five flavors of TCM,to excavate the prescription rules of TCM for the treatment of atrial fibrillation,and to excavate the core drugs for the treatment of atrial fibrillation through the association rule analysis of drug combinations. The core drugs were entered into the BATMAN-TCM system,to conduct disease enrichment and KEGG pathway analysis of the core drugs,and the target-pathway-disease network was drawn to explore the action mechanism of core drugs in the treatment of atrial fibrillation.[Results] According to inclusion and exclusion criteria,a total of 220 qualified prescriptions were included,involving 222 Chinese medicine,24 Chinese medicine with a frequency of ≥ 30 times,and the top 10 Chinese medicine were glycyrrhizae radix et rhizoma,ophiopogonis radix,salviae miltiorrhizae radix et rhizoma,astragali radix,schisandrea chinensis,ziziphi spinosae semen,angelicae sinensis radix,ostreae concha,codonopsis radix,cinnamomi ramulus. Four properties were mostly warm,cold,flat;the five flavors were mostly sweet,bitter,pungent. The top three meridians are heart,liver and spleen. Through association rule analysis,13 pairs of drug combinations with the use frequency ≥ 20 times in the prescriptions were obtained,including 9 Chinese medicine:ophiopogonis radix,schisandrea chinensis,glycyrrhizae radix et rhizoma,fossilia ossis mastodi,ostreae concha,astragali radix,salviae miltiorrhizae radix et rhizoma,ziziphi spinosae semen,cinnamomi ramulus. Six drug combination rules were obtained,namely:glycyrrhizae radix et rhizoma,schisandrea chinensis->ophiopogonis radix,fossilia ossis mastodi->ostreae concha,schisandrea chinensis->ophiopogonis radix,ostreae concha->fossilia ossis mastodi,cinnamomi ramulus->glycyrrhizae radix et rhizoma,ophiopogonis radix,glycyrrhizae radix et rhizoma->schisandrea chinensis,ophiopogonis radix,schisandrea chinensis->glycyrrhizae radix et rhizoma,ophiopogonis radix->schisandrea chinensis,schisandrea chinensis->glycyrrhizae radix et rhizoma,ziziphi spinosae semen->ophiopogonis radix,ostreae concha->glycyrrhizae radix et rhizoma,ziziphi spinosae semen->glycyrrhizae radix et rhizoma,ophiopogonis radix->glycyrrhizae radix et rhizoma,schisandrea chinensis->ophiopogonis radix,glycyrrhizae radix et rhizoma. The core drugs for the treatment of atrial fibrillation were found as follows:ophiopogonis radix,schisandrea chinensis,glycyrrhizae radix et rhizoma,Longgu,ostreae concha,astragali radix,codonopsis radix,ziziphi spinosae semen,cinnamomi ramulus. KEGG pathway analysis found that the enrichment of these 9 core drugs was associated with atrial fibrillation in 12 kinds of diseases and 36 potential signaling pathways.[Conclusion] Most of the drugs used in the clinical treatment of atrial fibrillation are based on supplementing qi and nourishing yin,activating blood and tranquilizing mind. The action mechanism of the core drugs in the treatment of atrial fibrillation may be related to mitogen-activated protein kinase(MAPK) signaling pathway,calcium signaling pathway,mammalian target of rapamycin(mTOR) signaling pathway and phosphatidylinositol 3 kinase-protein kinase B (PI3K-Akt) signaling pathway. |
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