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| Clinical research of chronic kidney disease stage 3 with hypothyroidism qi deficiency and blood stasis syndrome treated by Shenshuai Decoction |
| Hits 576 Download times 704 Received:February 11, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.06.08 |
| Key Words
chronic kidney disease stage 3;hypothyroidism;Shenshuai Decoction;curative efficiency;security |
| Author Name | Affiliation | | FAN Jun | Department of Nephrology, Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300120, China | | LIU Ze | Department of Nephrology, Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300120, China | | WANG Shen | Department of Nephrology, Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300120, China |
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| Abstract
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| Objective To observe the clinical efficacy of the modified "Shenshuai Decoction" of Professor ZHANG Daning's experience in the treatment of chronic kidney disease stage 3 (CKD3) patients with hypothyroidism ofqi deficiency and blood stasis.Methods The 60 patients with chronic kidney disease stage 3 combined with hypothyroidism of qi deficiency and blood stasis syndrome was selected, and the patients were divided into a treatment group and a control group by random grouping method, with 30 cases in each group. The control group was treated with conventional Western medicine, while the treatment group was added additionally with Shenshuai Decoction on the basis of conventional Western medicine. The clinical efficacy, glomerular filtration rate(eGFR), serum creatinine(SCr), homocysteine (Hcy), free thyroxine (FT4), thyroid-stimulating hormone (TSH) levels before and after the experiment were observed intwo groups, and the safety was evaluated.Results The total effective rate of the treatment group was 89.30%, which was significantly higher than 53.80% of the control group(P < 0.01). The levels of EGFR, SCR, Hcy, FT4 and TSH in treatment group were improved compared with those in control group (P < 0.05), and there was no adverse reaction.Conclusion The modified Shenshuai Decoction can significantly improve the clinical symptoms of patients, which not only improve the renal function, endocrine and lipid metabolism and other related clinical indicators, but also relieve the clinical symptoms and signs of patients, so as to improve renal fibrosis and adjust endocrine. |
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