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| Clinical observation on the treatment of Huixuan Zhenggu manipulation and Wenyang Tongluo Capsule on knee osteoarthritis with yang deficiency and cold coagulation syndrome |
| Hits 552 Download times 491 Received:January 15, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.06.09 |
| Key Words
Huixuan Zhenggu manipulation;Wenyang Tongluo Capsule;knee osteoarthritis;yang deficiency and cold coagulation |
| Author Name | Affiliation | | HONG Kunhao | Department of Orthopedics, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510095, China | | LIU Wengang | Department of Orthopedics, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510095, China | | CHEN Weijian | The Fifth Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou 510006, China | | WU Huai | Department of Orthopedics, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510095, China | | LIU Xin | Department of Orthopedics, Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510095, China |
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| Abstract
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| Objective To observe the short-term curative effect of using Huixuan Zhenggu manipulation combined with Wenyang Tongluo Capsule to treat knee osteoarthritis (KOA) with yang deficiency and cold coagulation syndrome.Methods The 71 patients with KOA treated in the Orthopedic Outpatient Department of Guangdong Second Traditional Chinese Medicine Hospital from October 2018 to February 2020 were selected, and they were randomly divided into experimental group (35 persons) and control group (36 persons). The experimental group was treated with Huixuan Zhenggu manipulation (once a week for 4 weeks) combined with Wenyang Tongluo Capsule (3 times a day, 2 tablets per time for 4 weeks), and the control group was treated with celecoxib capsule(2 times a day, 100 mg/time). The Visual Analogue Scale(VAS) score, Western Ontario and McMaster University Osteoarthritis Index(WOMAC) score, Self Rating Anxiety Scale (SAS) and self Rating Depression Scale (SDS) of the two groups were compared before and after treatment, and the curative effect of the two groups was evaluated.Results The cure rate in the experimental group was 14.29%, and the total effective rate was 91.43%. The cure rate in the control group was 13.89%, and the total effective rate was 86.11%. There was no statistically significant difference in the cure rate and total effective rate between two groups(P > 0.05). After treatment, the efficacy indicators of the two groups were significantly improved compared with the previous, the VAS and WOMAC scores were all decreased, and the difference was statistically significant (P < 0.05). After treatment, there was no significant difference in VAS score, WOMAC pain score, and stiffness score between two groups (P > 0.05). The WOMAC score of living ability in the experimental group decreased more significantly than the control group(P < 0.05). After treatment, the SAS and SDS scores of the two groups were significantly improved compared with before treatment, and the difference was statistically significant(P < 0.05). Comparing the groups after treatment, the SAS and SDS scores of the experimental group were improved more significantly than those of the control group (P < 0.05).Conclusion The treatment of Huixuan Zhenggu manipulation combined with oral Wenyang Tongluo Capsule can effectively relieve pain and improve joint function in KOA patients with yang deficiency and cold coagulation syndrome, and it has a positive effects on alleviating depression and anxiety in patients. |
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