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Randomized controlled study on the intervention effect of Qushi Jiangzhuo Decoction on islet function in patients with metabolic syndrome
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DOI   10.11656/j.issn.1672-1519.2022.07.10
Key Words   Fenxiao Zouxie method;metabolic syndrome;phlegm dampness syndrome;islet function
Author NameAffiliationE-mail
WANG Zhenqiang Internal Medicine Department of Traditional Chinese Medicine, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Hebei College of Traditional Chinese Medicine, Cangzhou 061001, China  
MA Yuanxin Internal Medicine Department of Traditional Chinese Medicine, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Hebei College of Traditional Chinese Medicine, Cangzhou 061001, China  
ZHANG Qingjiang Internal Medicine Department of Traditional Chinese Medicine, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Hebei College of Traditional Chinese Medicine, Cangzhou 061001, China  
LYU Shuquan Department of Diabetes, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Hebei College of Traditional Chinese Medicine, Cangzhou 061001, China  
CHEN Jingjing Internal Medicine Department of Traditional Chinese Medicine, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Hebei College of Traditional Chinese Medicine, Cangzhou 061001, China  
LU Siqi Department of Diabetes, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Hebei College of Traditional Chinese Medicine, Cangzhou 061001, China  
GENG Tao Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100051, China  
ZHANG Shufang Internal Medicine Department of Traditional Chinese Medicine, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Hebei College of Traditional Chinese Medicine, Cangzhou 061001, China  
SU Xiuhai Department of Diabetes, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Hebei College of Traditional Chinese Medicine, Cangzhou 061001, China  
ZHAO Yiran Hebei University, Baoding 071002, China lllxyr@126.com 
Abstract
    [Objective] To observe the effect of "Fenxiao Zouxie method" on the function of islets in patients with metabolic syndrome.[Methods] From January 2016 to December 2017,200 patients with metabolic syndrome were randomly selected for clinical study. Patients were divided into observation group and control group with random number method. The patients in the control group were given routine exercise and diet intervention,conventional drugs for hypertension,diabetes and hyperlipidemia,pioglitazone hydrochloride capsule,30 mg,once a day,orally for 60 days. The observation group in the control group on the basis of the treatment plan to increase the traditional Chinese medicine decoction Qushi Jiangzhuo Decoction. Compared the two groups before and after treatment related indicators,clinical efficacy,islet function.[Results] There was no significant difference in the levels of FBG,2 hPBG,HbA1c,TG,LDL,HDL,TC,DBP, SBP,body weight,waist circumference and BMI between the two groups before treatment(P>0.05). From the point of view of the group,after 60 days of treatment,each index of the two groups was improved compared with that before treatment,and the difference between two groups was significant (P<0.05). The total effective rate of the observation group was 98.00%,which was significantly higher than that of the control group (91.00%,P<0.05). There was no significant difference in the levels of HOMA2 IR,HOMA2 IS and HOMA2 IB between the two groups before treatment (P>0.05). After treatment,the levels of HOMA2 IR in the observation group were higher than those in the control group,and HOMA2 IS and HOMA2 IB were lower than those in the control group(P<0.05).[Conclusion] Qushi Jiangzhuo Decoction based on the theory of "Fenxiao Zouxie method" has a good clinical effect on the patients with metabolic syndrome. It not only improves the efficiency of treatment,but also improves the islet function. It has an important clinical application value.

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