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| Systematic evaluation of effectiveness and safety of Xuesaitong Soft Capsule in treating cerebral infarction |
| Hits 535 Download times 267 Received:February 17, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.07.16 |
| Key Words
Xuesaitong Soft Capsule;cerebral infarction;system evaluation;Meta analysis |
| Author Name | Affiliation | E-mail | | FENG Chaonan | Centre for Evidence-Based Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HU Haiyin | Centre for Evidence-Based Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JI Zhaochen | Centre for Evidence-Based Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | OU Yi | Centre for Evidence-Based Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | QIANG Xiaoyu | Centre for Evidence-Based Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WU Xiaolei | Centre for Evidence-Based Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Junhua | Centre for Evidence-Based Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CAO Lujia | Centre for Evidence-Based Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | caolujia0825@163.com |
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| Abstract
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| [Objective] To evaluate the efficacy and safety of Xuesaitong Soft Capsule in the treatment of cerebral infarction.[Methods] CNKI,Wanfang Database,VIP Database,China Biomedical Literature Database (SinoMed),PubMed and Embase Database were searched from construction to August 2021. Randomized controlled trials (RCTs) of Xuesaitong Soft Capsule in the treatment of cerebral infarction were retrieved,and the quality of the included studies was evaluated using the bias risk assessment tool recommended by the Cochrane Systematic Review Manual,and the efficacy and safety of Xuesaitong Soft Capsule were systematically evaluated.[Results] A total of 683 references were retrieved,and 16 RCTs were included,including 1 973 patients. The case data of 16 studies were complete,but trial registration and protocol approval were not conducted. 14 studies did not mention assignment concealment and subject blindness,of which 6 only referred to "randomization" but did not describe specific grouping methods,and 1 study did not adequately report methodological content in the results section. Meta-analysis results including clinical efficacy,NIHSS score and Barthel index and so on,13 studies reported clinical efficacy,and the combined results showed that the efficacy of conventional treatment combined with Xuesaitong Soft Capsule was superior to conventional treatment alone[OR=3.51(2.01,6.12),P<0.05]. NIHSS score was reported in 7 studies,and the combined results showed that the efficacy of conventional treatment combined with Xuesaitong Soft Capsule was superior to conventional treatment alone[MD=-3.29(-3.89,-2.70),P<0.05]. Barthel index was reported in 3 studies,suggesting that combined Xuesaitong Soft Capsule on the basis of conventional treatment had better efficacy than conventional treatment alone. Plasma viscosity was reported in 5 studies,and the combined results showed that combined xuesaitong soft capsule on the basis of conventional treatment had significantly better efficacy than conventional treatment alone[MD=-1.17(-1.64,-0.71),P<0.05]. Three studies reported the whole blood viscosity,and the combined results showed that combined Xuesaitong Soft Capsule on the basis of conventional treatment had significantly better efficacy than conventional treatment alone[MD=-4.88(-9.09,-0.67),P<0.05].[Conclusion] This study systematically evaluated the efficacy and safety of Xuesaitong Soft Capsule in the treatment of cerebral infarction,and the results showed that compared with conventional treatment alone,Xuesaitong Soft Capsule combined with conventional treatment can improve the clinical efficacy of cerebral infarction. Due to the quantity and quality of the included literature,the research conclusions need to be verified by more high-quality RCT studies. |
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