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| Study on reproductive regulation mechanism of Cupai Heji on ovulation disorder model rats with kidney yang deficiency |
| Hits 448 Download times 278 Received:April 15, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.07.20 |
| Key Words
Cupai Heji;kidney yang deficiency;ovulation disorder;reproductive endocrine function;regulatory mechanism |
| Author Name | Affiliation | E-mail | | SU Jian | Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300052, China | | | DU Xiaoqin | Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300052, China | dxq2384408797@126.com | | YE Juan | Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300052, China | | | ZHANG Yanan | Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300052, China | | | XING Li | Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300052, China | | | CHEN Yan | Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300052, China | | | KONG Xiao | Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300052, China | | | LIU Xueou | Tianjin Academy of Medical Sciences Hematology Hospital, Tianjin 300020, China | |
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| Abstract
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| [Objective] To explore the mechanism of the effect of Cupai Heji on reproductive endocrine function of ovulation disorder model rats with kidney yang deficiency.[Methods] The 60 healthy female SD rats were randomly divided into 6 groups according to the random number table method,with 10 rats in each group. Blank control group,model control group,clomiphene positive group,low dose,medium dose,and high dose groups of Cupai Heji were established respectively. Before death,the changes of estrous cycle of rats were observed and recorded,body weight and organ weight coefficient of rats in different groups were measured,and levels of hormones and factors related to oxidative stress response of hypothalamic pituitary ovarian axis (HPO axis) and hypothalamic pituitary adrenal axis (HPA axis) were detected.[Results] The body weight of rats in clomiphene positive group,low dose group,medium dose group and high dose group were significantly higher than those in model control group (P<0.05). The weight coefficients of various organs in clomiphene positive group,low,medium and high dose groups were significantly higher than those in model control group (P<0.05). The levels of serum P,GnRH,FSH,LH and E2 in clomiphene positive group,low,medium and high dose groups were significantly lower than those in blank control group,but significantly higher than those in model control group (P<0.05). The levels of serum ACTH and COR in clomiphene positive group,low,medium,and high dose groups were significantly lower than those in blank control group,but significantly higher than those in model control group (P<0.05). The levels of serum T-SOD and CAT in clomiphene positive group,low,medium and high dose groups were significantly lower than those in blank control group,and the levels of mad were significantly higher than those in blank control group. However,the levels of T-SOD and CAT were significantly higher than those in model control group,and the levels of mad were significantly higher than those in model control group (P<0.05).[Conclusion] Cupai Heji can promote the improvement of reproductive function and the development of reproductive organs in rats with kidney yang deficiency by improving the regulatory function of hypothalamus pituitary target gland axis and alleviating oxidative stress,which provides some pharmacological basis for the clinical promotion of Cupai Heji. |
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