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| Exploration on the mechanism of Bushen Huoxue Decoction on knee osteoarthritis with kidney deficiency and blood stasis based on network pharmacology |
| Hits 435 Download times 508 Received:March 20, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.07.21 |
| Key Words
Bushen Huoxue Decoction;kidney deficiency and blood stasis;network pharmacology;osteoarthritis of the knee;pathways |
| Author Name | Affiliation | E-mail | | SHI Jia | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Aifeng | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | draifeng@163.com | | JIN Bo | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CUI Zhongshang | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Congcong | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | |
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| Abstract
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| [Objective] To explore the key target and effect of Bushen Huoxue Decoction (BHD) in the treatment of knee osteoarthritis (KOA) with kidney deficiency and blood stasis.[Methods] The target of main active compounds in BHD was searched by Swiss Target Prediction. The disease targets of KOA were collected through Genecards database,and the intersection of the two was obtained to obtain a common target. Then,the STRING database was used to plot the protein interaction (PPI),and the GO and KEGG pathway enrichment analysis of key targets were performed.[Results] There were 82 active components and 615 potential targets of BHD. There were 482 targets for KOA diseases and 533 drug diseases. GO enrichment analysis obtained 119 cell biological items;95 related signaling pathways were obtained by KEGG pathway enrichment analysis.[Conclusion] The molecular mechanism of BHD in the treatment of KOA with multiple components,multiple pathways and multiple targets was expounded,which provided ideas for the follow-up research and clinical prescription. |
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