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| A randomized controlled study on the effects of Yiqi Yangrong Formula on immune function after chemotherapy in patients with spleen and kidney deficiency syndrome small cell lung cancer |
| Hits 1082 Download times 597 Received:February 10, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.08.05 |
| Key Words
Yiqi Yangrong Formula;spleen and kidney deficiency syndrome;small cell lung cancer;chemotherapy;myelosuppression;immune function |
| Author Name | Affiliation | E-mail | | WANG Zhenqiang | Cangzhou Hospital of Integrated TCM-WM Affiliated to Hebei University of Chinese Medicine, Cangzhou 061000, China | | | WANG Hongliang | Cangzhou Hospital of Integrated TCM-WM Affiliated to Hebei University of Chinese Medicine, Cangzhou 061000, China | | | CHEN Jingjing | Cangzhou Hospital of Integrated TCM-WM Affiliated to Hebei University of Chinese Medicine, Cangzhou 061000, China | | | ZHANG Qingjiang | Cangzhou Hospital of Integrated TCM-WM Affiliated to Hebei University of Chinese Medicine, Cangzhou 061000, China | | | ZHAO Yang | Cangzhou Hospital of Integrated TCM-WM Affiliated to Hebei University of Chinese Medicine, Cangzhou 061000, China | | | LI Xiaojiang | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | DONG Xueshan | Cangzhou Hospital of Integrated TCM-WM Affiliated to Hebei University of Chinese Medicine, Cangzhou 061000, China | | | ZHAO Fang | Cangzhou Hospital of Integrated TCM-WM Affiliated to Hebei University of Chinese Medicine, Cangzhou 061000, China | | | ZHANG Rui | North China University of Science and Technology, Tangshan 063210, China | | | ZHAO Yiran | Hebei University, Baoding 071002, China | lllxyr@126.com |
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| Abstract
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| [Objective] To observe the effect of Yiqi Yangrong Formula on immune function of small cell lung cancer patients with spleen and kidney deficiency syndrome. [Methods] From January 2018 to June 2019,120 patients with small cell lung cancer were randomly selected for this study. The patients were divided into observation group and control group,60 cases in each group. All patients were given EC scheme for chemotherapy. The patients in control group were given routine antiemetic,liver and stomach protection treatment. The patients in observation group were given Yiqi Yangrong Formula on the basis of the treatment scheme. The observation group and control group were continuously intervened in two chemotherapy cycles. The changes of blood routine,bone marrow suppression and immune function were compared between two groups before and after intervention. [Results] There was no significant difference in WBC,PLT, neut and Hb levels between two groups before the intervention (P>0.05). The above blood routine indexes of the two groups increased 14 days after one course of chemotherapy and 14 days after two courses of chemotherapy compared with that before the intervention (P<0.05),but the indexes of the observation group at each time point were higher than those of the control group,and there was statistical difference (P<0.05). Myelosuppression occurrence in the two groups after two times of chemotherapy had statistical difference in the degree of differentiation (P<0.05), the control group of patients with 0 degree bone marrow depression was lower than the observation group, and the control group of patients with Ⅲ and Ⅳ degree bone marrow depression was higher than the observation group. The incidence of myelosuppression in the observation group was lower than that in the control group (P<0.05),and there was no significant difference in CD3+ T,CD4+ T,CD8+ T,CD4+/CD8+,NK levels before chemotherapy between two groups (P>0.05). The levels of CD3+ T, CD4+ T,CD4+/CD8+,NK after two courses of chemotherapy were lower than those before chemotherapy (P<0.05),and there was no significant change in the level of CD8+ T (P>0.05). After chemotherapy,the level of CD4+ T in the observation group was lower than that before chemotherapy The level of CD4+/CD8+ was higher than that of the control group (P<0.05). There was no difference in the level of CD8+ T between two groups (P>0.05). [Conclusion] Yiqi Yangrong formula has a good therapeutic effect on the myelosuppression of patients with small cell lung cancer of spleen and kidney deficiency syndrome. It can reduce the incidence of myelosuppression and improve the immune function of patients. It should be widely used in clinical. |
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