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| Clinical study of Niaoduqing on intestinal microecology in patients with stage 3~4 chronic kidney disease |
| Hits 537 Download times 341 Received:March 04, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.08.06 |
| Key Words
Niaoduqing;chronic kidney disease;intestinal flora;inflammation |
| Author Name | Affiliation | E-mail | | ZHAI Liuyu | Department of Nephrology, Tianjin First Central Hospital, Tianjin 300192, China | | | HAN Yingying | Department of Nephrology, Tianjin First Central Hospital, Tianjin 300192, China | | | LU Ling | Department of Nephrology, Tianjin First Central Hospital, Tianjin 300192, China | | | ZHANG Wenyu | Department of Nephrology, Tianjin First Central Hospital, Tianjin 300192, China | | | SUN Na | Department of Nephrology, Tianjin First Central Hospital, Tianjin 300192, China | | | CHANG Wenxiu | Department of Nephrology, Tianjin First Central Hospital, Tianjin 300192, China | changwx@sina.com |
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| Abstract
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| [Objective] To explore the effect of Niaoduqing Granule on intestinal microflora in non-dialysis patients with chronic kidney disease (CKD) at stage 3~4. [Methods] The 60 non-dialysis patients with chronic kidney disease (CKD) at stage 3~4 were employed and randomly divided into CKD group (30 cases) and Niaoduqing group (30 cases). The patients in Niaoduqing group were treated with Niaoduqing Granule on the basis of routine treatment in CKD group. In addition,10 healthy volunteers were employed as control group. The changes of intestinal flora diversity and composition,serum inflammatory factor and urinary toxin levels,and renal function were observed before and 3 months after the test. [Results] The 2 cases and 3 cases were respectively lost to follow up in CKD group and Niaoduqing group,finally 28 cases and 27 cases were included respectively. Before the test,compared with the control group,the intestinal flora in CKD group and Niaoduqing group changed significantly,and the levels of serum urotoxin,inflammatory factors and renal function indexes were significantly higher (P<0.05). Three months after the test,compared with CKD group,the diversity of intestinal flora in Niaoduqing group increased,and the flora composition were closer to the flora distribution of the control group. In addition,the level of C-reactive protein (CRP) in Niaoduqing group had the tendency of downward,while the level of indoxyl sulfate (IS) and some renal function indexes such as serum creatinine (Scr) and albumin-to-creatinine ratio (ACR) decreased significantly (P<0.05). [Conclusion] The intestinal flora of CKD patients changed significantly. The intervention of Niaoduqing could regulate the imbalance of intestinal flora at a certain extent,reduce the state of inflammatory reaction,and delay the progress of CKD. The correlation between the imbalance of intestinal flora and the change of renal function needs to be further studied. |
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