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| Effect of Jiajian Kaiyu Zhongyu Recipe combined with group psychotherapy for the endometrial receptivity of unexplained infertility female with liver stasis and kidney deficiency syndrome |
| Hits 547 Download times 344 Received:February 10, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.08.08 |
| Key Words
unexplained infertility;Jiajian Kaiyu Zhongyu Recipe;group psychotherapy;endometrial receptivity |
| Author Name | Affiliation | E-mail | | ZHAO Zhimei | Reproductive Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | CHAO Chun'e | Reproductive Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | ZHANG Jing | Reproductive Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | MA Saihua | Reproductive Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | saihua1002@126.com |
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| Abstract
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| [Objective] To investigate the effect on endometrial receptivity in unexplained infertility (UI) patients with liver stasis and kidney deficiency syndrome when treated by Jiajian Kaiyu Zhongyu Recipe combined with group psychological intervention. [Methods] A total of 90 patients with UI who met the criterion from the Reproductive Center of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from November 2018 to November 2019 were randomly assigned to Traditional Chinese Medicine (TCM) group,control group and the TCM combined with group psychological intervention group (combination group).The patients in TCM group received Jiajian Kaiyu Zhongyu Recipe (JJKYZY)daily from menstrual day 5 for fourteen days eachcourse,and a total of 3 courses of treatment were taken,with follicular monitoring. The patients in the control group received expectant treatmentfor 6 months. The patients in the combination group were given 6 times of group psychological intervention on the basis of the TCM group. Indicators included theindicators related to endometrial receptivity (including endometrial thickness,endometrial classification,subendometrial blood flow status and dynamic parameters of uterine artery on HCG day),andthe level of serum vascular endothelial growth factor (VEGF). [Results] 1)The indicators related to endometrial receptivity：the endometrial thickness,type A endometrium,blood flow under the endometrium of the combination group and the endometrial thickness of TCM group were significantly improved after treatment (P＜ 0.05),and compared with the control group,the indicators mentionedabove were also significantly improved (P＜0.05). The sum of bilateral perfusion index (PI) and resistance index (RI),uterine artery systolic peak flow rate/end-diastolic flow rate ratio (S/D)of combination group and TCM group were significantly reduced after treatment (P＜0.05),while these indicators in the control group were significantly increased after treatment (P＜0.05). The indicators mentionedabove of combination group and TCM group were also significantly decreased comparing to the control group (P＜0.05),and the sum of bilateral RI of the combination group was significantly decreased comparing to the TCM group (P＜0.05). 2) The level of serum VEGF：the level of serum VEGF in the combination group and TCM group were significantly improved after treatment (P＜0.05). [Conclusion] Jiajian Kaiyu Zhongyu recipe combined with group psychotherapy can improve the endometrial thickness,morphology and uterine artery blood perfusion,thereby improve endometrial receptivity. |
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