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| Study on the law of drug use in the treatment of constipation based on data mining with patent of Chinese medicine |
| Hits 528 Download times 443 Received:January 25, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.08.14 |
| Key Words
data mining;constipation;association rule;clustering;patent;medication rule |
| Author Name | Affiliation | E-mail | | SONG Zhihui | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Caijun | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | FENG Wanying | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Lin | Tianjin Zhongxin Pharmaceutical Group Co., Ltd. Le Ren Tang Pharmaceutical Factory, Tianjin 300112, China | | | WANG Yujing | Tianjin Zhongxin Pharmaceutical Group Co., Ltd. Le Ren Tang Pharmaceutical Factory, Tianjin 300112, China | | | WANG Yi | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wangyi@tjutcm.edu.cn |
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| Abstract
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| Study on the law of drug use in the treatment of constipation based on data mining with patent of Chinese medicine[Objective] To apply data mining to analyze the prescription rules of Chinese medicine patents for the treatment of constipation,and to provide a basis for clinical medication. [Methods] Screen all the information about the treatment of constipation with Chinese medicine patents,use excel to count the frequency of use of Chinese medicine,the four qi and five flavors,meridian,efficacy and classification. SPSS modeler 18.0 for association rule analysis. SPSS statistics 22.0 for cluster statistics and factor analysis. [Results] A total of 1 373 Chinese medicine prescriptions and 12 123 Chinese medicines were included,30 of them were used more than 100 times, such as Angelica,Cistanche,Hemp seed,etc. The medicinal property was mild and cold for the most part,while the medicinal taste was sweet and bitter for the most part,the main meridian were the spleen and stomach,and the liver meridian. The association rule counts had 8 drug pairs,clustering was divided into 5 categories. [Conclusion] The core drugs for the treatment of constipation were Angelica, Cistanche,Hemp seed,etc.,which were commonly combined with rhubarb-Fructus aurantii aurantii-Magnolia officinalis. Rehmannia glutinosa Libosch-Radix Ginseng-Radix Ophiopogonis. The treatment principle was to moisten the intestine and relieve constipation,and also to clear heat and detoxification,sooth liver and regulate qi. |
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