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| Clinical research evaluation outcomes and related problems of traditional Chinese medicine in the treatment of childhood epilepsy |
| Hits 501 Download times 417 Received:March 04, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.08.17 |
| Key Words
child;epilepsy;clinical trial;outcome |
| Author Name | Affiliation | E-mail | | WU Shangbin | Department of Pediatrics, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510000, China
Wen Ziyuan Academic School Inheritance Studio of Lingnan Pediatrics of Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510000, China | | | ZHU Zheng | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CHEN Xinying | Department of Pediatrics, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510000, China | | | YANG Jinghua | Department of Pediatrics, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510000, China | | | WANG Hui | Evidence-based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wangh@tice.com.cn |
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| Abstract
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| [Objective] This study systematically sorted out the evaluation outcomes of the randomized controlled trials of traditional Chinese medicine for the treatment of childhood epilepsy,aiming to provide a preliminary research basis for the research on the core outcome set of traditional Chinese medicine for the treatment of childhood epilepsy. [Methods] Randomized controlled trials of traditional Chinese medicine in the treatment of childhood epilepsy in CNKI,WanFang Data,SinoMed,PubMed,The Cochrane Library,and Embase databases were systematically searched. Two researchers independently screened the literature and extracted information according to the inclusion and exclusion criteria,standardized and classified the evaluation outcomes,and performed descriptive statistics on the results. [Results] A total of 57 randomized controlled trials were included,with treatment durations ranging from 15 to 720 days. The minimum number of patients included was 37 and the maximum was 190. The included studies used 95 evaluation outcomes,a total of 206 times. After the indicators are normalized,there are a total of 21 evaluation outcomes,which are classified into 5 domains. [Conclusion] The evaluation outcomes of clinical research on the treatment of childhood epilepsy with traditional Chinese medicine have problems such as irregular use of outcome names,unclear names and quantities of primary and secondary outcomes,irregular selection of safety outcomes, and neglect of economic outcomes and long-term prognosis outcomes. It is urgent to establish a core outcome set that conforms to the characteristics of epilepsy and traditional Chinese medicine treatment to provide guidance for clinical research design of traditional Chinese medicine in the treatment of childhood epilepsy. |
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