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| Clinical efficacy evaluation of Xuanfei Baidu Granule in the treatment of Omicron virus infection with COVID-19 |
| Hits 642 Download times 380 Received:March 20, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.09.02 |
| Key Words
COVID-19;Omicron strain;traditional Chinese medicine;Xuanfei Baidu Granule;clinical evaluation |
| Author Name | Affiliation | E-mail | | PANG Wentai | Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | YANG Fengwen | Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHENG Wenke | Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | FENG Jihong | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | 493507647@qq.com | | XU Qiang | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | tcmxuqiang@hotmail.com | | ZHANG Lei | Tianjin Hospital, Tianjin 300210, China | zhangleitj2008@163.com |
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| Abstract
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| [Objective] To evaluate the efficacy and safety of Xuanfei Baidu Granule (XFBD) in the treatment of COVID-19 infected with Omicron virus strain.[Methods] A total of 180 patients with mild/normal COVID-19 infected with Omicron strain were included.Patients were assigned into two groups according to their wishes:the experimental group received XFBD combined with conventional treatment (120 cases),the control group received conventional treatment (60 cases).The primary outcomes were virus nucleic acid negative conversion time and length of hospital stay.The secondary outcomes were symptom disappearance rate,severe case rate and mortality rate.The safety outcomes were adverse events.[Results] The time of virus nucleic acid turning negative in the experimental group was 8(6,10) d,and the length of hospital stay was 11(9,13) d,which was shorter than the control group[10(7,11) days,12(10.5,13.5) d],the difference between groups was statistically significant (P <0.05).The disappearance rate of cough,phlegm,throat discomfort,xerostomia and other symptoms in the experimental group was better than that in the control group.No severe cases or death occurred in the two groups,and no treatment-related adverse events were observed.[Conclusion] In the treatment of Omicron virus strain infected COVID-19,XFBD can relieve the symptoms,shorten the time of viral nucleic acid negative conversion safely. |
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