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| Clinical trials and evaluation of Chinese patent medicine for arrhythmia |
| Hits 457 Download times 617 Received:May 03, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.09.15 |
| Key Words
Chinese patent medicine;arrhythmia;randomized controlled trial;evidence-based medicine |
| Author Name | Affiliation | E-mail | | HU Haiyin | Evidence-based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | JI Zhaochen | Evidence-based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | FENG Chaonan | Evidence-based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | PENG Dehui | Evidence-based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SHENG Xiaodi | Evidence-based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Hui | Evidence-based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wangh@tice.com.cn |
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| Abstract
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| [Objective] This study reviewed the clinical randomized controlled trials (RCTs) of Chinese patent medicine for arrhythmia to provide references for clinical research,guideline development,and policy formulation.[Methods] EVDS,PubMeb,Web of Science were searched for RCTs of Chinese patent medicine for arrhythmia from database inception to December 31,2020.[Results] A total of 1 934 RCTs were included,involving 100 Chinese patent medicines,including 82 oral medicines and 18 injections.Treatment course of 64.89% RCTs were 15 to 30 d;38.00% of RCTs had a sample size of more than 100 cases;65 types of interventions/controls were involved in the RCTs,with Chinese patent medicine+Western medicine vs.western medicine as the top one used (27.25%).In outcomes,symptoms/signs (3 106) and physicochemical detection (2 616) were the most frequently applied.High difference were in the methodological quality between Chinese RCTs and English RCTs.RCTs'methodological quality were not improve in near 4 years.[Conclusion] Many deficiencies in the RCTs of Chinese patent medicine for arrhythmia,such as small study size,not clear clinical value proposition,study design that fails to reflect the value of Chinese patent medicine,unscientific outcomes,unreasonable measured methods.Future studies should give priority to above problem and solve them,improving the quality and value of studies and enhancing the reliability and extrapolation of evidence. |
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