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| The role of endothelial cell in coronary myocardial no-reflow phenomenon and advances on the protective effect of traditional Chinese medicine |
| Hits 488 Download times 449 Received:May 13, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.09.24 |
| Key Words
endothelial cell;myocardial ischemia-reperfusion;no-reflow;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | LI Peijie | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHENG Xianxian | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ODURO Patrick Kwabena | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LENG Ling | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin 301617, China | | | LI Yuhong | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin 301617, China | | | LI Ruiqiao | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin 301617, China | liruiqiao@tjutcm.edu.cn | | WANG Qilong | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Tianjin 301617, China | |
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| Abstract
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| Percutaneous coronary intervention is the best reperfusion strategy for acute ST-segment elevation myocardial infarction.However,after coronary artery stenosis has been released,microcirculation to the part of the infarcted tissue is impaired.This phenomenon is termed "no-reflow",and it is a strong predictor of heart failure and increased mortality among ST segment elevation myocardial infarction patients.Endothelial cells play an important role in no-reflow and are a research hotspot in recent years.In view of this,injury to cardiac microvascular endothelial cells contributes significantly to myocardial "no-reflow" phenomenon.This article discusses the endothelial cell damage involved in no-reflow and the research progress of traditional Chinese medicine in improving endothelial cell injury and no-reflow was summarized. |
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