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| Clinical evaluation of Tianjiang Xueshuantong Pill combined with rt-PA intravenous thrombolytic therapy for acute ischemic stroke |
| Hits 540 Download times 334 Received:June 18, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.10.03 |
| Key Words
Tianjiang Xueshuantong Pill;ischemic stroke;efficacy evaluation;neurological function |
| Author Name | Affiliation | E-mail | | LI Yinghong | Department of Encephalopathy, Tianjin Beichen Traditional Chinese Medicine Hospital, Tianjin 300400, China | 姚庆萍，yaoqingping@yeah.net | | YAO Qingping | Department of Encephalopathy, Tianjin Beichen Traditional Chinese Medicine Hospital, Tianjin 300400, China | |
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| Abstract
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| [Objective] To evaluate the clinical efficacy of Tianjiang Xueshuantong Pills (TXP) combined with rt-PA intravenous thrombolysis in patients with acute ischemic stroke of different ages.[Methods] The clinical data of 271 patients with wind-phlegm-blocking acute ischemic stroke treated with rt-PA intravenous thrombolysis admitted from January 2017 to February 2020 were retrospectively studied.They were divided into the elderly group (≥ 65 years old) and the middle-aged group (<65 years old) according to their age,and further divided into the treatment group and the control group according to whether received TXP treatment.All patients were given conventional internal medicine treatment.After 30 days of continuous treatment,the NIHSS scores,traditional Chinese medicine (TCM) syndrome scores,mRS scores,and BI scores were compared,and the clinical efficacy was evaluated.[Results] The NIHSS scores of patients in all groups were significantly reduced after treatment.The difference in the NIHSS scores of the elderly group before treatment was statistically significant,and after excluding their interference,the mRS scores decreased and the BI scores increased in the treatment group compared with the control group,which were statistically significant (P<0.05).There was no significant change in mRS scores and BI scores in the treatment group compared to the control group in the middle-aged group (P>0.05).The TCM syndrome scores of each group were decreased after treatment,and the scores of the treatment group were lower than those of the control group in the elderly patients (P <0.05).The total clinical efficiency rates of treatment group and control group was 91.04% and 73.02%,respectively,with a significant difference (P<0.05).There was no significant difference in TCM syndrome scores and efficacy between the treatment group and the control group after treatment in the middle-aged group (P>0.05).[Conclusion] Oral administration of TXP can effectively improve the clinical symptoms and promote physical recovery in elderly patients with acute ischemic stroke,but the efficacy in young and middle-aged patients is poor. |
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