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| Effect and safety of Yangxin Dingji Capsule combined with Western medicine for cardiac function indexes among patients with arrhythmia:a Meta-analysis |
| Hits 545 Download times 294 Received:August 20, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.10.11 |
| Key Words
Yangxin Dingji Capsule;arrhythmias;systematic review;Meta-analysis;randomized controlled trial |
| Author Name | Affiliation | E-mail | | JI Zhaochen | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | 庞博，pangbo2021@163.com | | HU Haiyin | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Kai | The Key Laboratory of Classical Prescription Strengthening Yang of Shanxi Provincial Department of Science and Technology, Taiyuan 030013, China | | | WANG Hui | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CAO Lujia | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Junhua | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | PANG Bo | Evidence Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | |
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| Abstract
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| [Objective] To systematically evaluate the therapeutic advantages and safety of Yangxin Dingji Capsules combined with conventional Western medicine in improving cardiac function indexes and safety among patients with arrhythmia.[Methods] CNKI,WanFang Data,VIP,SinoMed,PubMed,Cochrane Library,Embase and Web of Science were searched to collect randomized controlled trials (RCTs) of Yangxin Dingji Capsules combined with conventional Western medicine for arrhythmia from the establishment of the database to November 31,2021.Two reviewers independently screened the literature and extracted data.Any disagreements were resolved through discussion,and RevMan 5.3 software was used for data analysis.[Results] A total of 242 literatures were retrieved,and 27 articles were finally included,including 2 665 patients.According to the results of meta-analysis,compared with conventional Western medicine alone,Yangxin Dingji Capsules combined with conventional Western medicine showed significant advantages in improving the following clinical indicators,including the total clinical effective rate[OR=3.04,95%CI(2.45,3.76),P<0.000 01],frequency of premature ventricular contraction[MD=-1.49,95%CI(-2.00,-0.99),P<0.000 01],premature atrial contraction[MD=-1.19,95%CI(-1.60,-0.77),P<0.000 01]and the paroxysmal atrial fibrillation[MD=-40.98,95%CI(-51.34,-30.63),P<0.000 01],heart rate variability index including SDNN[MD=9.96,95%CI(4.22,15.70),P=0.000 7],SDANN[MD=10.44,95%CI(4.56,16.31),P=0.000 5]and RMSSD[MD=4.34,95%CI(0.96,7.71),P=0.01],Cardiac Doppler ultrasound index including LVEF[MD=4.56,95%CI(3.25,5.86),P<0.000 01],LVEDD[MD=-6.91,95%CI(-11.95,-1.86),P=0.007]and LVESD[MD=-4.34,95%CI(-5.79,-2.88),P<0.000 01].In addition,the incidence of adverse events in Yangxin Dingji Capsule combined with conventional Western medicine treatment was lower than that in conventional Western medicine control[OR=0.49,95%CI(0.36,0.66),P<0.000 01].[Conclusion] Current evidence supports that Yangxin Dingji Capsules combined with conventional Western medicine has advantages in improving cardiac function indexes and clinical efficacy in patients with arrhythmia,with good safety.However,due to the limited quantity and quality of literature,more randomized controlled,multicenter,large-sample clinical trials are still needed to provide high-quality evidence. |
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